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Glossary Promoter Region

specific DNA sequence where RNA polymerase binds to initiate transcription

The promoter region is a specific sequence of DNA located near the start of a gene that acts as a binding site for RNA polymerase and other transcription factors. This region essentially "promotes" the initiation of transcription, the process by which the genetic code from DNA is copied into messenger RNA (mRNA). Understanding promoter regions is crucial in fields like genetics and molecular biology, as they play a key role in regulating gene expression.

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Research

5 / 1000+ results

research Characterization of the Promoter Regions of Two Sheep Keratin-Associated Protein Genes for Hair Cortex-Specific Expression

14 citations , April 2016 in “PloS one”

This study found that the promoter region of the sheep KRTAP11-1 gene drives specific transcriptional activity in wool follicles, suggesting it may regulate hair keratinocyte specificity.

research Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population

8 citations , January 2015 in “Genetics and Molecular Research”

This study found that specific SNPs in the CXCL1 and CXCL2 genes may be associated with increased susceptibility to alopecia areata in the Korean population.

research Functional mapping of the mouse hairless gene promoter region

January 2018 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study identified a new cis-regulatory element in the mouse Hr gene that influences its expression in skin and brain cells, highlighting a complex molecular network involved in hair follicle formation.

research Association between DNA Methylation in the Core Promoter Region of the CUT-like Homeobox 1 (CUX1) Gene and Lambskin Pattern in Hu Sheep

1 citations , September 2023 in “Genes”

This study found no significant difference in CUX1 core promoter methylation levels between different lambskin patterns in Hu sheep, suggesting other mechanisms influence CUX1 expression related to hair follicle development.

research Single nucleotide polymorphisms in the KRT82 promoter region modulate irregular thickening and patchiness in the dorsal skin of New Zealand rabbits

2 citations , May 2024 in “BMC Genomics”

This study analyzed the genetics of the patchiness phenotype in New Zealand rabbits and found that the gene KRT82, with identified SNPs in its promoter, may serve as a potential biomarker for breeding these rabbits.

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Community Join

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community 0.5mg Dutasteride promotes more “regrowth” than 5mg oral Minoxidil

in Research/Science 117 upvotes 2 years ago

Dutasteride promotes more hair regrowth than Minoxidil. Users discuss combining treatments for better results and share personal experiences with side effects.

community It is kind of diabolical how this works

1574 upvotes 6 months ago

DHT promotes hair growth in certain areas but causes scalp hair loss, highlighting a frustrating irony. Minoxidil is mentioned as a treatment that grows hair everywhere, including the scalp.

community Fixing DHT Itch (scalp inflammation) with Aloe Vera gel & more

12 upvotes 1 year ago

Aloe vera gel can help reduce scalp inflammation and "DHT itch" associated with hair loss, particularly in those with androgenic alopecia and seborrheic dermatitis. It's suggested to use aloe vera alongside treatments like finasteride and ketoconazole shampoo to manage symptoms and promote scalp health.

community Why does the same hormone grow your beard and destroy your hairline?

44 upvotes 4 months ago

DHT promotes beard growth but causes scalp hair loss due to inflammation and fibrosis. Treatments like finasteride and minoxidil help with hormonal signals and blood flow but don't address underlying inflammation.

community Been on Oral Minoxidil for 50 days. It definitely works!

9 upvotes 9 years ago

Oral Minoxidil (Loniten) effectively promotes hair regrowth, especially on the crown and temples, with minimal side effects like extra body hair. The user found it more convenient and effective than topical Minoxidil and had negative experiences with Finasteride and Dutasteride.

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Learn

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learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Stem Cell Factor

learn Beta Polypeptide

learn Thymosin Beta 4

learn Lavender

Does lavender promote hair growth or just soothe an irritated scalp? Lavender may promote hair growth and soothe an irritated scalp.

learn Dexpanthenol

Does dexpanthenol promote hair growth? Dexpanthenol improves hair moisture and strength but does not directly promote hair growth.

learn Setipiprant

How does Setipiprant work on the scalp to potentially promote hair regrowth? Setipiprant blocks the DP2 (CRTH2) receptor that prostaglandin D₂ acts through, and PGD₂ is reported to be elevated in balding scalp — but the one published placebo-controlled trial in men (DuBois 2021, n=169) found no significant hair regrowth. It is an experimental compound, not an approved hair-loss medicine.

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