Polymorphisms in the Promoter Regions of the CXCL1 and CXCL2 Genes Contribute to Increased Risk of Alopecia Areata in the Korean Population

    January 2015 in “ Genetics and Molecular Research ”
    Sooyeon Kim, Chung Jh, Hi‐Joon Park, Sang Wook Kang, Dong-Gyun Lim, Seong‐Eun Byun, Daehyun Baek, Hyun Ko, Bark‐Lynn Lew, Hee Jung Baik, Woo‐Young Sim
    TLDR Certain gene variations increase the risk of alopecia areata in Koreans.
    This study investigated the correlation between single nucleotide polymorphisms (SNPs) in the promoter regions of the CXCL1 and CXCL2 genes and the development of alopecia areata (AA) in the Korean population. It included 235 AA patients and 240 control subjects. The SNPs rs3117604 and rs3806792 were genotyped, and statistical analyses revealed significant associations between these SNPs and AA development. Specifically, the TT and CC haplotypes were significantly associated with an increased risk of AA. The findings suggested that the CXCL1 and CXCL2 genes might be linked to AA susceptibility.
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