Association Between Interleukin 18 Polymorphisms and Alopecia Areata in Koreans
January 2014
in “
Journal of Interferon & Cytokine Research
”
TLDR Certain genetic variations in IL18 may increase the risk of alopecia areata in Koreans.
This study investigated the association between IL18 single-nucleotide polymorphisms (SNPs) and alopecia areata (AA) in a Korean population, involving 233 AA patients and 243 healthy controls. Two SNPs, rs187238 and rs549908, were genotyped and analyzed. Both SNPs showed significant associations with AA development across multiple genetic models, suggesting that IL18 may be a risk factor for AA susceptibility.
