Association Between Interleukin 18 Polymorphisms and Alopecia Areata in Koreans

    January 2014 in “ Journal of Interferon & Cytokine Research ”
    Su Kang Kim, Hae Jeong Park, Joo‐Ho Chung, Jong-Woo Kim, Ho-Sik Seok, Bark‐Lynn Lew, Woo‐Young Sim
    TLDR Certain genetic variations in IL18 may increase the risk of alopecia areata in Koreans.
    The study investigated the association between interleukin 18 (IL-18) polymorphisms and alopecia areata (AA) in a Korean population, involving 200 AA patients and 200 healthy controls. It found that certain IL-18 gene variants, specifically the G allele of rs187238 and the A allele of rs549908, were significantly more frequent in the AA group, suggesting a genetic predisposition to AA linked to IL-18 polymorphisms. This indicated that IL-18 could play a role in the pathogenesis of alopecia areata, providing a potential target for future therapeutic strategies.
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