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GlossaryInterleukin-18 (IL18)

cytokine that promotes inflammation and immune responses

Interleukin-18 (IL-18) is a cytokine, a type of protein that plays a crucial role in the immune system by promoting inflammation. It is involved in the body's defense mechanisms against infections and has been linked to various inflammatory and autoimmune conditions, including alopecia areata, where it can contribute to hair loss by triggering an immune response against hair follicles.

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research CDK9 Kinase Activation in Association with AFF1-SEC Initiates Epidermal Progenitor Differentiation

November 2022 in “Journal of Investigative Dermatology”

NCSTN gene mutation causes abnormal skin cell differentiation and more inflammation, contributing to Hidradenitis Suppurativa.

Skin Organoids Derived From NCSTN Mutated Patient-Induced Pluripotent Stem Cells Recapitulate Hidradenitis Suppurativa Pathogenic Hallmarks

research Skin Organoids Derived From NCSTN Mutated Patient-Induced Pluripotent Stem Cells Recapitulate Hidradenitis Suppurativa Pathogenic Hallmarks

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin organoids with NCSTN mutation show changes in hair follicle development and higher inflammation, key features of Hidradenitis Suppurativa.

research Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells

51 citations, October 2019 in “Cells”

Baricitinib reduces inflammation and improves cell health in premature aging cells.

research Association Between Interleukin 18 Polymorphisms and Alopecia Areata in Koreans

22 citations, January 2014 in “Journal of Interferon & Cytokine Research”

Certain genetic variations in IL18 may increase the risk of alopecia areata in Koreans.

Integrated Single-Cell Chromatin and Transcriptomic Analyses of Human Scalp Reveal Etiological Insights Into Genetic Risk for Hair and Skin Disease

research Integrated Single-Cell Chromatin and Transcriptomic Analyses of Human Scalp Reveal Etiological Insights Into Genetic Risk for Hair and Skin Disease

September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

The research provided new insights into the genetic factors contributing to hair loss and skin conditions by analyzing individual cells from the human scalp.

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