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GlossaryInterleukin-18 (IL18)

cytokine that promotes inflammation and immune responses

Interleukin-18 (IL-18) is a cytokine, a type of protein that plays a crucial role in the immune system by promoting inflammation. It is involved in the body's defense mechanisms against infections and has been linked to various inflammatory and autoimmune conditions, including alopecia areata, where it can contribute to hair loss by triggering an immune response against hair follicles.

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research IL-18 Signaling Promotes Homing of Mature Tregs into the Thymus

July 2020

IL-18 signaling helps mature Tregs move into the thymus.

research Decision Letter: IL-18 Signaling Promotes Homing of Mature Tregs into the Thymus

May 2020

IL-18 signaling helps mature Tregs move into the thymus.

research Association Between Interleukin 18 Polymorphisms and Alopecia Areata in Koreans

22 citations, January 2014 in “Journal of Interferon & Cytokine Research”

Certain genetic variations in IL18 may increase the risk of alopecia areata in Koreans.

research Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells

51 citations, October 2019 in “Cells”

Baricitinib reduces inflammation and improves cell health in premature aging cells.

Skin Organoids Derived From NCSTN Mutated Patient-Induced Pluripotent Stem Cells Recapitulate Hidradenitis Suppurativa Pathogenic Hallmarks

research Skin Organoids Derived From NCSTN Mutated Patient-Induced Pluripotent Stem Cells Recapitulate Hidradenitis Suppurativa Pathogenic Hallmarks

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin organoids with NCSTN mutation show changes in hair follicle development and higher inflammation, key features of Hidradenitis Suppurativa.

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