TLDR The study found that a specific genetic variation in the TNFα gene is significantly linked to Alopecia Areata in the Jordanian Arab population.
In 2019, a case-control study was conducted on 152 patients with Alopecia Areata (AA) and 150 healthy individuals from the Jordanian Arab population. The study investigated the genetic association of 7 single-nucleotide polymorphisms (SNPs) within five candidate genes (TAP1, CXCL1, CXCL2, HSPA1B, and TNFα) with AA susceptibility. The results showed that the rs1800629 SNP of the TNFα gene was significantly associated with AA in the heterozygous and rare homozygous genotypes (P=0.022 and P=0.0079, respectively). However, no significant associations were found with the TAP1, CXCL1, CXCL2, and HSPA1B variants. The study concluded that AA is polygenic and that TNFα plays a significant role in its pathogenesis. The researchers suggested further genetic studies on Arab descent including other variants to strengthen the association of these genes with susceptibility to develop AA.
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