Association Between IL16 Gene Polymorphisms and Susceptibility to Alopecia Areata in the Korean Population

This study investigated the association between IL16 gene polymorphisms and alopecia areata (AA) in the Korean population, involving 229 AA patients and 270 control subjects. Significant differences were found for two single nucleotide polymorphisms (SNPs) of the IL16 gene: rs17875491 between AA patients and controls, and rs11073001 between AA patients with and without a family history of AA. These findings suggested that IL16 polymorphisms might influence the pathophysiology and phenotypic expression of AA, warranting further research to clarify IL-16's role in AA.