TLDR IL16 gene variations may affect the risk of alopecia areata in Koreans.
The study investigated the association between IL16 gene polymorphisms and alopecia areata (AA) in the Korean population, involving 229 AA patients and 270 control subjects. It found significant differences in two single nucleotide polymorphisms (SNPs) of the IL16 gene: rs17875491 between AA patients and controls, and rs11073001 between AA patients with and without a family history of the disease. These findings suggested that IL16 polymorphisms might influence the pathophysiology and phenotypic expression of AA, warranting further research to understand IL-16's role in AA.
391 citations,
January 2010 in “Journal of The American Academy of Dermatology” Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.
185 citations,
August 2005 in “Autoimmunity Reviews” Alopecia areata is an autoimmune condition causing hair loss due to the immune system attacking hair follicles, often influenced by genetics and stress.
January 2023 in “International Journal of Zoological Investigations” Certain genetic variations in IL-16 may increase the risk of alopecia areata.
34 citations,
October 2017 in “Archivos Argentinos De Pediatria” Alopecia Areata is a complex, unpredictable autoimmune hair loss condition with limited treatment options and a significant psychological impact.
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June 2023 in “Genes” Hair loss from Alopecia Areata is caused by both genes and environment, with several treatments available but challenges in cost and relapse remain.
47 citations,
December 2019 in “Frontiers in immunology” A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.
1 citations,
January 2017 in “Springer eBooks” Understanding the immune-related causes of Alopecia Areata has led to potential treatments like JAK inhibitors.
