Genetic Single Nucleotide Polymorphisms of IL-16 and Its Concentration in Patients Infected with Alopecia Areata in Diyala Province, Iraq

January 2023 in “ International Journal of Zoological Investigations ”

Muna Hameed Ahmed Al-Azzawi, Munir D. Nazzal, Iowa Hassan, Ali Hafedh Abbas

alopecia areata IL-16 single nucleotide polymorphisms SNPs cytokines AA genetic research

TLDR Certain genetic variations in IL-16 may increase the risk of alopecia areata.

This study examined the genetic association of IL-16 single nucleotide polymorphisms (SNPs) with alopecia areata (AA) in Diyala Province, Iraq, involving 51 AA patients and 50 healthy controls. It found non-significant increases in IL-16 serum levels in AA patients. The GG genotype and G allele of rs11325 were non-significantly higher in patients, while the TC and CC genotypes and C allele of rs1131445 were significantly higher. These findings suggest that specific IL-16 SNPs may be risk factors for AA, emphasizing the need for further genetic research on cytokines in AA susceptibility.

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