Identification of Two Novel Clusters of Ultrahigh-Sulfur Keratin-Associated Protein Genes on Human Chromosome 11

    May 2004 in “ Biochemical and Biophysical Research Communications ”
    Shoichi Yahagi
    TLDR Two new gene clusters important for hair formation were found on human chromosome 11.
    The study identified two novel clusters of keratin-associated protein (KAP) genes on human chromosome 11, specifically at 11p15.5 and 11q13.5. These clusters included two known KRTAP5 genes and nine novel KRTAP5 family genes, all of which were classified as ultrahigh-sulfur (UHS) type KAPs due to their high cysteine content. The research suggested that these genes are preferentially expressed in human hair roots, indicating their role in hair formation. The study proposed that these gene clusters were generated through genomic duplication and subsequent genetic modification.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 154 results

      community Keratin microspheres - breakthrough

      in Research/Science  14 upvotes 1 year ago
      A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

      community Comprehensive Microneedling Guide

      in Microneedling  293 upvotes 3 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Results of Procyanidin B2 in clinical studies

      in Treatment  11 upvotes 5 years ago
      Procyanidin B2, a compound derived from Annurca apples, as a potential treatment for pattern hair loss. Several clinical studies were mentioned, which found that procyanidin B2 could increase hair growth, density, and keratin content. Other treatments such as Minoxidil, Finasteride, and RU58841 were not discussed.

      community Dec 2024 vs now (min + fin/dut)

      in Progress Pictures  25 upvotes 5 days ago
      The user experienced hair thickening and reduced shedding using minoxidil, finasteride, and dutasteride, with a switch from finasteride to dutasteride due to ineffectiveness. They also use a saw palmetto shampoo and take vitamin D3 supplements, while considering potential underlying causes like vitamin deficiencies and hard water buildup.

    Similar Research

    5 / 1000+ results