Glucoraphanin and Sulforaphane Biosynthesis Mediated by Melatonin and Nitric Oxide in Hairy Roots of Broccoli: Insights from Transcriptome Data

    August 2022 in “ BMC Plant Biology ”
    Shaoying Ma, Jinsong Bao, Yaqi Lu, Xu Lu, Peng Tian, Xiaoling Zhang, Jie Yang, Xiaotong Shi, Zhihui Pu, Sheng Li
    Image of study
    TLDR Melatonin helps broccoli roots produce anti-cancer compounds by controlling nitric oxide and hydrogen peroxide levels.
    The study explored the role of melatonin (MT) in the synthesis of glucoraphanin (GRA) and sulforaphane (SF), compounds found in broccoli with anti-cancer properties. Using hairy roots of broccoli treated with 500 μmol/L MT, it was found that MT regulates the synthesis of nitric oxide (NO) and hydrogen peroxide (H2O2), which mediate the synthesis of GRA and SF. The highest yields of these compounds and NO content were observed at 12 hours of MT treatment. NO synthase inhibitors reduced NO content and GRA and SF yield, but MT counteracted this effect by regulating NO synthesis-related enzymes. The study concluded that MT can regulate the synthesis of GRA and SF in broccoli hairy roots by mediating NO and H2O2, providing insights into the complex molecular mechanism of MT's regulation of GRA and SF biosynthesis.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 294 results

      community Thoughts of this sub on Melatonin?

      in Research/Science  3 upvotes 1 month ago
      Melatonin, gingko biloba, and biotin are effective for treating hair loss with good tolerability. Alternatives like dutasteride, minoxidil, and other peptides are also discussed.

      community Melatonin emerging as new treatment for androgenic alopecia?

      in Update  37 upvotes 4 months ago
      Melatonin is being considered as a potential treatment for androgenic alopecia, with some users discussing its effects and combining it with other treatments like minoxidil and finasteride. Concerns about melatonin's impact on hormones and side effects from other treatments like ketoconazole were also discussed.

      community Is anyone using melatonin for hair loss?

      in Research/Science  9 upvotes 10 months ago
      Melatonin is being discussed as a potential treatment for hair loss, with questions about its effectiveness and whether it should be used topically or orally. No specific conclusions or personal experiences were shared.

      community Melatonin options for Europe??? *Retrograde Alopecia*

      in Product  3 upvotes 11 months ago
      A user is considering using melatonin for hair recovery on the side and neck area but is unsure about the best options in Europe and whether a dietary supplement form can be applied to the scalp. They found a product but are hesitant and seeking opinions on its use for alopecia.

      community Optimal dose for topical Melatonin

      in Treatment  6 upvotes 1 year ago
      The conversation is about finding the optimal concentration of topical melatonin for hair loss treatment. The user is considering making their own solution and is unsure whether a higher concentration is more effective for deactivating prolactin receptors.

    Related Research

    1 / 1 results