Mechanical Engineering of Hair Follicle Regeneration by In Situ Bioprinting

    September 2022 in “ Biomaterials advances
    Haiyan Chen, Yi Zhang, Dezhi Zhou, Xiaoxiao Ma, Siming Yang, Tao Xu
    TLDR 3D bioprinting can effectively regenerate hair follicles and skin tissue in wounds.
    This study explored the use of a 3D bioprinting machine for in situ bioprinting of epidermal stem cells (Epi-SCs), skin-derived precursors (SKPs), and Matrigel directly into wound sites of nude mice to promote hair follicle regeneration. The results showed complete wound healing and functional skin tissue regeneration, including the formation of epidermis, dermis, blood vessels, hair follicles, and sebaceous glands within 4 weeks. The bioprinting process only slightly decreased stem cell viability and maintained the stemness of the stem cells, indicating its potential for clinical applications in hair follicle regeneration.
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