Mechanical Engineering of Hair Follicle Regeneration by In Situ Bioprinting

    September 2022 in “ Biomaterials advances ”
    Haiyan Chen, Yi Zhang, Dezhi Zhou … Tao Xu
    Studysummary This study used 3D bioprinting to implant epidermal stem cells, skin-derived precursors, and Matrigel into mouse wounds, successfully regenerating hair follicles and skin components within four weeks, with minimal impact on stem cell viability and stemness.
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    Research cited in this study 22

    1. 3D Bioprinting of a Gelatin-Alginate Hydrogel for Tissue-Engineered Hair Follicle Regeneration Acta Biomaterialia · 2022
    2. May the Best Wound WIHN: The Hallmarks of Wound-Induced Hair Neogenesis Current Opinion in Genetics & Development · 2021
    3. Engineered Skin Substitute Regenerates Skin with Hair Follicle Formation Biomedicines · 2021
    4. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    5. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    6. Tissue Engineering Strategies for Human Hair Follicle Regeneration: How Far From a Hairy Goal? Stem Cells Translational Medicine · 2019
    7. Preparation of Hair Beads and Hair Follicle Germs for Regenerative Medicine Biomaterials · 2019
    8. Pten Loss In Lgr5+ Hair Follicle Stem Cells Promotes SCC Development Theranostics · 2019
    9. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    10. Embryonic-Like Regenerative Phenomenon: Wound-Induced Hair Follicle Neogenesis Regenerative Medicine · 2018
    11. Impact on Quality of Life in Patients with Androgenetic Alopecia Undergoing Hair Transplantation Surgery in a Clinic Journal of Nepal Medical Association · 2018
    12. Msx2 Supports Epidermal Competency During Wound-Induced Hair Follicle Neogenesis Journal of Investigative Dermatology · 2018
    13. Bottom-Up Nanoencapsulation from Single Cells to Tunable and Scalable Cellular Spheroids for Hair Follicle Regeneration Advanced Healthcare Materials · 2017
    14. Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors Stem Cells Translational Medicine · 2016
    15. Self-Assembling Peptide Hydrogel Scaffolds Support Stem Cell-Based Hair Follicle Regeneration Nanomedicine: Nanotechnology, Biology and Medicine · 2016
    16. Bioengineering a 3D Integumentary Organ System from iPS Cells Using an In Vivo Transplantation Model Science Advances · 2016
    17. Hair Restoration Surgery: Challenges and Solutions Clinical, Cosmetic and Investigational Dermatology · 2015
    18. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    19. SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells Cell stem cell · 2009
    20. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    21. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    22. Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia Journal of Investigative Dermatology · 2004

    Related research 5

    1. Mechanical Engineering of Hair Follicle Regeneration by In Situ Bioprinting Biomaterials advances · 2022
    2. Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence Cell reports · 2015
    3. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    4. Stem Cells in Embryonic Skin Development Biological Research · 2012
    5. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011