29 citations
,
January 2016 in “Experimental Dermatology” This article discusses how mechanical stress may contribute to the development of hidradenitis suppurativa lesions, drawing on historical research and highlighting the possible role of IL-17-mediated inflammation.
11 citations
,
November 1996 in “Pediatric dermatology” This paper reviews trichostasis spinulosa and presents a case in a 13-year-old girl, providing no new clinical research results.
98 citations
,
July 1968 in “Archives of Dermatology” This study found that applying scalp sebum from young men to rabbit ear canals caused follicular hyperkeratosis, suggesting sebum stimulates the formation of comedones, a key feature in acne vulgaris.
July 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” This study used single-cell transcriptomic analysis to identify a specific cell population in acne patients' non-lesional skin, providing evidence for the comedone switch hypothesis by suggesting a shift towards infundibular differentiation at the expense of sebaceous gland maintenance.
47 citations
,
January 2015 in “Dermatology” This review revisits mechanisms underlying acne lesion formation and suggests that preventing comedone development requires controlling critical factors in the pilosebaceous follicle before acne involvement.