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    Glossary Hedgehog Pathway Inhibitors

    drugs that block cell growth signals to treat cancer

    Hedgehog Pathway Inhibitors are drugs that block the Hedgehog signaling pathway, which is crucial for cell growth and differentiation during embryonic development. In adults, abnormal activation of this pathway can lead to cancers such as basal cell carcinoma. By inhibiting this pathway, these drugs can help treat certain types of cancer by preventing the uncontrolled growth of cancer cells.

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    Research 30 of 1000+

    1. Roles of the Hedgehog Signaling Pathway in Cutaneous Physiology and Oncology International journal of dermatology and venereology · 2019
    2. From basal cell carcinoma morphogenesis to the alopecia induced by hedgehog inhibitors: connecting the dots British Journal of Dermatology · 2017 · 17 citations
    3. Basal Cell Carcinoma, Hedgehog Signaling, and Targeted Therapeutics: The Long and Winding Road Journal of Investigative Dermatology · 2014 · 15 citations
    4. WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling Experimental & Molecular Medicine · 2021 · 36 citations
    5. Dermal T cell immunity and key regulatory signaling pathways: Implications in immune-mediated alopecia and hair regeneration Genes & Diseases · 2025 · 1 citations
    6. Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK / STAT1 signaling pathway FEBS Open Bio · 2025
    7. Aberrant Wnt Signaling Induces Comedo-Like Changes in the Murine Upper Hair Follicle 2021 · 4 citations
    8. Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened Clinical cancer research · 2011 · 63 citations
    9. Vitamin E promotes dermal papilla cell proliferation via the lncRNA2919/STAT1 axis to activate the Hedgehog signaling pathway Non-coding RNA Research · 2026
    10. Hedgehog Pathway Inhibitors against Tumor Microenvironment Cells · 2021 · 21 citations
    11. Aberrant Activation of the Hedgehog Pathway in Cutaneous Melanoma: Therapeutic Potential of Pharmacological Inhibitors International Journal of Molecular Sciences · 2026
    12. Abstract CN06-04: The hedgehog signaling pathway in cancer. Molecular Cancer Therapeutics · 2011
    13. Aberrant Activation of the Hedgehog Signaling Pathway in Malignant Hematological Neoplasms ˜The œAmerican journal of pathology · 2011 · 68 citations
    14. Cutaneous adverse effects of targeted therapies Journal of the American Academy of Dermatology · 2015 · 149 citations
    15. Management of Dermatologic Toxicities Journal of the National Comprehensive Cancer Network · 2015 · 12 citations
    16. Chemotherapy-Induced Hair Loss: The Use of Biomarkers for Predicting Alopecic Severity and Treatment Efficacy Biomarker Insights · 2019 · 10 citations
    17. 085 Dermal papilla cells control hair follicle matrix keratinocytes proliferation through versican Journal of Investigative Dermatology · 2024
    18. Understanding Cancer Cells of Origin in Cutaneous Tumors Elsevier eBooks · 2016 · 1 citations
    19. Oncogenes and morphogens: intricacies of targeted therapy in cutaneous basal cell carcinoma British Journal of Dermatology · 2017
    20. The HEDGEHOG-GLI1 pathway is important for fibroproliferative properties in keloids and as a candidate therapeutic target Communications biology · 2023
    21. AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma Nature Communications · 2020 · 60 citations
    22. Emerging drugs and combination strategies for basal cell carcinoma Expert opinion on emerging drugs · 2014 · 19 citations
    23. Potential roles of FGF5 as a candidate therapeutic target in prostate cancer. PubMed · 2023 · 2 citations
    24. Skin Deep and Deeper: Multiple Pathways in Basal Cell Carcinogenesis Cancer Prevention Research · 2010 · 5 citations
    25. Keloid pathogenesis and fibroproliferative properties are dependent on stem cells regulated by the HEDGEHOG-GLI1 pathway Research Square (Research Square) · 2023
    26. The E6/E7 oncogenes of human papilloma virus and estradiol regulate hedgehog signaling activity in a murine model of cervical cancer Experimental Cell Research · 2019 · 9 citations
    27. WISP-1 induced by mechanical stress contributes to the fibrosis and hypertrophy of ligamentum flavum via the Hedgehog-Gli1 signaling 2020
    28. Experience with sonidegib in patients with advanced basal cell carcinoma: case reports Drugs in Context · 2022 · 9 citations
    29. Molecular biology of hair morphogenesis: Development and cycling Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution · 2003 · 155 citations
    30. Embryonic hair follicle fate change by augmented β-catenin through Shh and Bmp signaling Development · 2009 · 54 citations