Classification and Management of Skin, Hair, Nail, and Mucosal Side Effects of Epidermal Growth Factor Receptor Inhibitors
February 2007
in “
European journal of cancer
”
TLDR EGFR inhibitors often cause skin problems and other side effects, but these are usually reversible and can be managed to keep patients comfortable.
The document discusses the side effects of epidermal growth factor receptor (EGFR) inhibitors, which are drugs used in cancer treatment. It notes that these inhibitors frequently cause skin and related toxicities, with about 85% of patients experiencing an acneiform eruption, 35% developing xerosis cutis (dry skin), and 10-15% suffering from painful nail disorders. Hair and mucosal changes are also mentioned but are less common. These side effects are typically reversible once treatment is stopped and rarely lead to discontinuation of therapy. The review provides a classification of these side effects, explores their pathogenesis, and suggests management strategies. It emphasizes the importance of patient education and side effect management to improve patient comfort and treatment adherence.
