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Research

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research Through the lens of hair follicle neogenesis, a new focus on mechanisms of skin regeneration after wounding

28 citations , October 2019 in “Seminars in Cell & Developmental Biology”

This article discusses the advances in understanding wound-induced hair follicle neogenesis (WIHN) and highlights the roles of specific signaling pathways and cellular plasticity, noting no clinical results but suggesting potential areas for further research.

research FGF9 for baldness

1 citations , June 2013 in “Science-business Exchange”

In this study, researchers at the University of Pennsylvania found that increasing FGF9 levels in wounded mouse skin can lead to the growth of hair follicles.

research Phenotypic Analysis of T-Cells in Extensive Alopecia Areata Scalp Suggests Partial Tolerance

21 citations , December 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study demonstrates that T-cell responses in extensive alopecia areata scalp may be aberrantly regulated, with reduced cytokine production but activated phenotype, providing insight into the disease's immune mechanisms.

research Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells

58 citations , January 2006 in “Skin Pharmacology and Physiology”

This study found that testosterone and 5α-dihydrotestosterone induced apoptosis in dermal papilla cells from nonbalding scalp regions, suggesting a high androgen stimulus can trigger cell death related to androgenetic alopecia.

research Direct cellular reprogramming enables development of viral T antigen–driven Merkel cell carcinoma in mice

14 citations , February 2022 in “The Journal of clinical investigation/The journal of clinical investigation”

This study found that the development of Merkel cell carcinoma from hair follicles in mice can be driven by in vivo reprogramming with ATOH1 and relies on p53 loss for progression.

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Community Join

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community (21) Finesteride hasn’t lowered my DHT after 8 months. Has anyone else experienced this?

in Finasteride/Dutasteride 24 upvotes 2 years ago

A user experienced no reduction in DHT levels after 8 months of finasteride, despite initial improvement in hair loss. They are considering switching to dutasteride but are concerned about potential side effects.

community Fin isn’t working anymore after 3 years, afraid to switch to dut?

in Finasteride/Dutasteride 27 upvotes 2 years ago

Finasteride stopped working for a user after 3 years, and they are considering switching to dutasteride. Other users suggest trying dutasteride, with some sharing positive experiences and additional treatments like minoxidil and RU58841.

community 21 y.o. Would really appreciate some advice.

6 upvotes 12 years ago

A 21-year-old is experiencing worsening hair loss and has tried Rogaine and Propecia, considering generics due to cost. They are advised to consider finasteride, hair transplant surgery, or PRP therapy, while also expressing concerns about potential side effects and waiting for a dermatologist appointment.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 3 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community How true is the statement: dead follicles don't grow back?

112 upvotes 1 year ago

Hair follicles usually go dormant rather than die, and treatments like finasteride, minoxidil, and hormone therapy can sometimes reactivate them, though results vary. Complete regrowth is rare, especially in long-term bald areas, but some individuals see significant improvement with these treatments.

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Learn

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learn Scalp Micropigmentation

How should you care for your scalp after Scalp Micropigmentation to keep the results looking natural? Avoid sweating, sun exposure, and washing for 3-7 days after scalp micropigmentation.
Will anyone notice my scalp micropigmentation treatment? Providers say well-done SMP is hard to spot, but results depend on the artist, and poor work can look artificial and is hard to correct (Park 2025, PMID 38822591).

learn Hair Transplant

Is a hair transplant painful? Clinics say local anaesthetic makes the procedure itself mostly comfortable, but the anaesthetic injections sting and soreness for a few days afterwards is common. Pain varies from person to person.
What is the difference between FUE and DHI hair transplants? FUE creates channels before implantation, while DHI uses a pen for direct placement.

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