Expression and Function of Nuclear Receptor Co-Activator 4: Evidence of a Potential Role Independent of Co-Activator Activity

The document from May 5, 2012, reviews the role and potential functions of Nuclear receptor coactivator 4 (NcoA4), which is involved in the regulation of various nuclear receptors and may have roles beyond its coactivator activity. NcoA4 enhances androgen receptor (AR) transcriptional activity and affects ligand specificity, which could influence hormonal therapies for prostate cancer. It also interacts with other nuclear receptors and may influence cell proliferation, migration, and division independently of its coactivator role. The review suggests that NcoA4 could be involved in cytoplasmic events affecting receptor activity and stability, as well as cell division and genomic stability. Further research is needed to fully understand NcoA4's regulation and function.