Will hair regenerate if androgen receptors are nuked?
Research/Science 2/22/2023
androgen receptors AR receptor blockers AR receptor degraders hair transplants DHT HMI androgen blockers fibrosis AGA GT20029 androgen receptor blockers androgen receptor degraders dihydrotestosterone androgenetic alopecia
Treatments for hair loss, such as using AR receptor blockers and degraders, to see if follicles can regenerate in the long term. The conversation also discusses how hair transplants could be a potential solution.
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5 / 1000+ resultscommunity Minoxidil is able to suppress androgen receptors or increase aromatase effect. Blood test in pictures.
A 24-year-old male experienced an increase in estradiol levels and symptoms like gynecomastia and excessive sweating after using Minoxidil for hair loss. His estradiol levels decreased after he stopped using Minoxidil.
community If we lose hair because of our sensitivity to DHT, then why are we trying to reduce DHT when our sensitive androgen receptors are the culprit?
The conversation discusses the effectiveness of reducing DHT for hair loss treatment and explores alternative approaches like reducing androgen receptor sensitivity. Specific treatments mentioned include finasteride, dutasteride, pyrilutamide (KX-826), GT20029, and RU58841.
community Is regrowth on an androgen receptor blocker possible?
RU and Pyri block androgen receptors to prevent hair loss but may also hinder hair regrowth since they prevent testosterone, which can stimulate hair growth, from binding to these receptors. The user is questioning if this understanding is correct.
community Fluridil downregulates androgen receptor expression?
Fluridil may decrease the number of androgen receptors in hair follicles by up to 95%. This suggests a different action mechanism from other non-steroidal antiandrogens like RU58841, indicating they might be used together.
community Why Cant we just find an effective androgen receptor antagonist that works locally on the scalp?
Researching and developing an effective local antagonist to block the androgen receptors for hair loss, as opposed to using DHT synthesis inhibitors that lower serum DHT levels. Several treatments such as CosmeRNA and Pyrilutamide are currently in development or undergoing trials.
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