Cellular and Molecular Characterization of Sebaceous Gland Self-Renewal and Regeneration Following Complete Genetic Ablation

April 2023 in “ Journal of Investigative Dermatology ”

N.A. Veniaminova, Y. Jia, A. Hartigan, T. Huyge, S. Tsai, M.A. Grachtchouk, S. Nakagawa, A. Dlugosz, S. Atwood, S. Wong

sebaceous gland PPARg hair follicle reepithelization single cell RNA-sequencing FGFR signaling hair cycle sebocyte Peroxisome proliferator-activated receptor-gamma skin healing RNA-sequencing fibroblast growth factor receptor signaling hair growth cycle

TLDR The research found that a protein called PPARg is important for the formation and healing of sebaceous glands, which can regenerate independently from hair follicles.

The study "Cellular and molecular characterization of sebaceous gland self-renewal and regeneration following complete genetic ablation" by Veniaminova, Dlugosz, and Wong from the University of Michigan, reveals the role of Peroxisome proliferator-activated receptor-gamma (PPARg) in sebaceous gland (SG) formation and regeneration. The researchers found that PPARg is expressed in the SG progenitor compartment and that SGs are maintained independently of the hair follicle during homeostasis. However, upon wounding, SG cells contribute to skin reepithelization and are replaced by hair follicle-derived cells. The study also identified three putative sebocyte cell states through targeted single cell RNA-sequencing. When PPARg was deleted in adult skin, most SGs regenerated within 5-10 weeks, a process highly dependent on both the hair cycle and FGFR signaling. This research provides insights into the cellular interplay that governs SG behavior during homeostasis, injury, and regeneration.

View this study on jidonline.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 57 results

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 1 upvotes 2 weeks ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 411 upvotes 2 weeks ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 57 upvotes 1 month ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 3 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

Similar Research

5 / 1000+ results

research Molecular Regulation and Cellular Heterogeneity in Skin Repair and Hair Follicle Regeneration

January 2019

Ovol2 is crucial for hair growth and skin healing by controlling cell movement and growth.

research PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

9 citations, June 2023 in “Cells”

Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.