Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors

May 2023 in “ Journal of Endocrinology and Reproduction ”

Leemon Nikhila, Suresh Senan, Shahul Hameed Najeeb, T. M. Binumon, Parameswara Panicker Sreejith

Primary Cicatricial Alopecia cholesterol biosynthesis TGFβ AGTR Epithelial Mesenchymal Transition siRNA PPARγ AhR PCA transforming growth factor beta angiotensin receptor EMT small interfering RNA peroxisome proliferator-activated receptor gamma aryl hydrocarbon receptor

TLDR Blocking cholesterol production may help control hair loss in Primary Cicatricial Alopecia by affecting key regulators.

The study investigates the role of cholesterol biosynthesis inhibition in Primary Cicatricial Alopecia (PCA), a hair loss condition. Researchers used small interfering RNAs (siRNA) of TGFβ, AGTR, and their regulators to study the modulation of Epithelial Mesenchymal Transition (EMT), a process potentially affected by PCA. Findings suggest that reduced cholesterol production leads to permanent hair follicle damage in PCA patients. The study also found that PPARγ, AhR, and AGTR can act as vital EMT regulators. The study concludes that EMT in hair loss can be regulated by suppressing cholesterol biosynthesis, suggesting cholesterol and EMT modulators as potential inhibitors in PCA etiology.

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