Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors

    May 2023 in “ Journal of Endocrinology and Reproduction ”
    Leemon Nikhila, Suresh Senan, Shahul Hameed Najeeb … Parameswara Panicker Sreejith
    Studysummary This study found that in primary cicatricial alopecia, reducing cholesterol production and targeting EMT modulators like PPARγ, AhR, AGTR, and TGFβ with siRNA may help mitigate hair follicle damage by modulating epithelial-mesenchymal transition, suggesting potential therapeutic strategies for slowing PCA progression.
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    Research cited in this study 19

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