FLCN, A Novel Autophagy Component, Interacts With GABARAP And Is Regulated By ULK1 Phosphorylation

July 2014 in “ Autophagy ”

Elaine A. Dunlop, Sara Seifan, Tijs Claessens, Christian Behrends, M. Kamps, Ewelina Rozycka, Alain J. Kemp, Ravi K. Nookala, John Blenis, Barry J. Coull, James T. Murray, M.A.M. van Steensel, Simon Wilkinson, Andrew R. Tee

folliculin autophagy GABARAP ULK1 phosphorylation autophagic flux cellular homeostasis BHD syndrome autophagy markers renal tumors

TLDR The protein FLCN is involved in cellular cleanup and is regulated by ULK1.

The study identified folliculin (FLCN) as a novel component of the autophagy process, interacting with GABARAP and regulated by ULK1 phosphorylation. Loss of FLCN impaired autophagic flux, which was rescued by re-expression of FLCN. The research highlighted FLCN's role in cellular homeostasis and its potential implications in diseases related to autophagy dysfunction, such as BHD syndrome, where impaired autophagy and elevated autophagy markers were observed in renal tumors. The findings provided new insights into the molecular mechanisms of autophagy and suggested potential therapeutic targets for related diseases.

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research FLCN, A Novel Autophagy Component, Interacts With GABARAP And Is Regulated By ULK1 Phosphorylation

60 citations, July 2014 in “Autophagy”

The protein FLCN is involved in cellular cleanup and is regulated by ULK1.

FLCN, A Novel Autophagy Component, Interacts With GABARAP And Is Regulated By ULK1 Phosphorylation

Research cited in this study

research Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion

research Folliculin Interacts With P0071 (Plakophilin-4) and Deficiency Is Associated With Disordered RhoA Signalling, Epithelial Polarization, and Cytokinesis

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