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GlossaryCYP11A1

enzyme converting cholesterol to pregnenolone, initiating steroid hormone production

CYP11A1, also known as Cytochrome P450 Family 11 Subfamily A Member 1 or P450scc, is an enzyme crucial for the production of steroid hormones. It catalyzes the conversion of cholesterol to pregnenolone, the first step in the biosynthesis of all steroid hormones, which are vital for various bodily functions including stress response, immune function, and regulation of inflammation.

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Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

402 citations, August 2011 in “Cancer research”

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

research Steroidogenesis of the Testis: New Genes and Pathways

70 citations, May 2014 in “Annales d'endocrinologie”

New genes and pathways are important for testosterone production and male sexual development.

research In Search of New Therapeutics: Molecular Aspects of the PCOS Pathophysiology - Genetics, Hormones, Metabolism and Beyond

44 citations, September 2020 in “International Journal of Molecular Sciences”

New treatments are needed for PCOS that target its genetic, hormonal, and metabolic causes.

research Genetic Variants Associated with Hyperandrogenemia in PCOS Pathophysiology

29 citations, February 2018 in “Genetics research international”

Certain genetic variations are linked to increased androgen levels in PCOS, but more research is needed to understand these connections fully.

research Endocrine Systems of the Skin: A 2019 Review

9 citations, January 2019 in “Postepy Dermatologii I Alergologii”

The skin acts like an endocrine organ, making hormones that affect skin diseases and respond to stress.

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community NootBro Recommendations… How Do We Feel

in Research/Science 10 upvotes 3 months ago

The conversation is about hair loss treatments, specifically a stack including topical Ashwagandha, Copper Peptide, Gotu Kola, Ketoconazole, and PDA. One user found Topical and Sub-Q GHK-CU effective.

community Is Keto shampoo 2% even worth starting?

in Ketoconazole 45 upvotes 1 month ago

Ketoconazole shampoo is primarily for scalp health and reducing inflammation, not hair regrowth. Combining ketoconazole with finasteride can yield similar results to using minoxidil and finasteride together.

community My hairloss stack, progress pics soon maybe for 1 year RU

in Technology 49 upvotes 1 year ago

The conversation is about a user's hair loss treatment routine, which includes RU58841 for 9 months and Dutasteride for 6 months, with other unspecified treatments considered extra. One user inquired about the source of RU58841.

community Dutasteride Literally Saves Your Hair

in Finasteride/Dutasteride 97 upvotes 3 months ago

Dutasteride significantly reduces scalp DHT levels and can save hair, though shedding is part of the process. Some users report success with dutasteride, while others struggle despite using it along with finasteride and oral minoxidil.

community We need to keep these snake oil companies accountable.

in Treatment 124 upvotes 3 months ago

Biotin is being misleadingly marketed as a primary treatment for androgenic alopecia, overshadowing more effective treatments like finasteride and minoxidil. There is a call for increased awareness and accountability to prevent misinformation.

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