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    Glossary CYP11A1

    enzyme converting cholesterol to pregnenolone, initiating steroid hormone production

    CYP11A1, also known as Cytochrome P450 Family 11 Subfamily A Member 1 or P450scc, is an enzyme crucial for the production of steroid hormones. It catalyzes the conversion of cholesterol to pregnenolone, the first step in the biosynthesis of all steroid hormones, which are vital for various bodily functions including stress response, immune function, and regulation of inflammation.

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    Research 30 of 552

    1. Intratumoral <i>De Novo</i> Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors Cancer research · 2011 · 402 citations
    2. The significance of CYP11A1 expression in skin physiology and pathology Molecular and Cellular Endocrinology · 2021 · 91 citations
    3. Association of Cyp11a Gene with Polycystic Ovarian Syndrome Patients in Lahore, Pakistan Pakistan Journal of Health Sciences · 2025
    4. Genetic screening of non-classic CAH females with hyperandrogenemia identifies a novel CYP11B1 gene mutation Hormones · 2016
    5. Investigation of variants of the aromatase gene (CYP19A1) in female pattern hair loss British Journal of Dermatology · 2011 · 15 citations
    6. CYP21A2 Genotypes do not Predict the Severity of Hyperandrogenic Manifestations in the Nonclassical Form of Congenital Adrenal Hyperplasia Hormone and Metabolic Research · 2013 · 14 citations
    7. The Associations of Androgen-Related Genes CYP21A2 and CYP19A1 with Severe Acne Vulgaris in Patients from Southwest China Clinical Cosmetic and Investigational Dermatology · 2021 · 10 citations
    8. CYP21A2 Mutations in Women with Polycystic Ovary Syndrome (PCOS) Hormone and Metabolic Research · 2013 · 9 citations
    9. Association of Single Nucleotide Polymorphisms in the CYP19A1 Gene with Female Pattern Hair Loss in a Chinese Population Dermatology · 2015 · 7 citations
    10. Effect of a Benign Prostatic Hyperplasia (BPH) Xenobiotic - Croton membranaceus Müll.Arg. Root Extract on CYP1A2, CYP3A4, CYP2D6, and GSTM1 Drug Metabolizing Enzymes in Rat Model 2020 · 1 citations
    11. MitoQ upregulates CYP19A1 to protect dermal papilla cells from DHT-induced mitochondrial dysfunction and apoptosis in androgenetic alopecia Biochemical Pharmacology · 2026
    12. Coconut oil works as a gonadal feedback testosterone booster and increases pituitary aromatase (cyp19a1b) expression levels in fugu (Takifugu rubripes) Aquaculture · 2025
    13. Exploring the role of CYP19A1 single nucleotide polymorphisms in the pathogenesis of female pattern hair loss Egyptian Journal of Dermatology and Venerology · 2025
    14. MitoQ enhances CYP19A1 expression to stimulate WNT/β-catenin signaling pathway for promoting hair growth in androgenetic alopecia European Journal of Pharmacology · 2024
    15. 8368 Functional Evaluation Of Novel CYP21A2 Variants: Expanding The Genetic Basis Of Non-classic CAH Journal of the Endocrine Society · 2024
    16. 9209 Functional Evaluation Of Novel CYP21A2 Variants: Expanding The Genetic Basis Of Non-classic CAH Journal of the Endocrine Society · 2024
    17. First case of V281+I172N/V281L CYP21A2 genotype associated with congenital adrenal hyperplasia form. A case report from South Italy Clinical Biochemistry · 2007
    18. The role of CYP19A1 and ESR2 gene polymorphisms in female androgenetic alopecia in the Polish population Postepy Dermatologii I Alergologii · 2021
    19. Detection of mutations in the CYP21A2 gene: genotype-phenotype correlation in Slovenian couples with conceiving problems Balkan Journal of Medical Genetics · 2015 · 1 citations
    20. Steroidogenesis of the testis – new genes and pathways Annales d'endocrinologie · 2014 · 70 citations
    21. Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts The Journal of Steroid Biochemistry and Molecular Biology · 2009 · 57 citations
    22. In Search of New Therapeutics—Molecular Aspects of the PCOS Pathophysiology: Genetics, Hormones, Metabolism and Beyond International Journal of Molecular Sciences · 2020 · 44 citations
    23. Genetic Variants Associated with Hyperandrogenemia in PCOS Pathophysiology Genetics research international · 2018 · 29 citations
    24. Clinical-exome sequencing unveils the genetic landscape of polycystic ovarian syndrome (PCOS) focusing on lean and obese phenotypes: implications for cost-effective diagnosis and personalized treatment Scientific Reports · 2024 · 13 citations
    25. Endocrine systems of the skin Postepy Dermatologii I Alergologii · 2019 · 9 citations
    26. Acquired 11β-hydroxylase Deficiency by Inhaled Etomidate and its Analogues: A Mimic of Congenital Adrenal Hyperplasia JCEM Case Reports · 2024 · 2 citations
    27. A review of hyperandrogenism state in polycystic ovarian syndrome International journal of reproduction, contraception, obstetrics and gynecology · 2023
    28. Genetics and Epigenetics of Polycystic Ovary Syndrome IntechOpen eBooks · 2023
    29. New Target for Minoxidil in the Treatment of Androgenetic Alopecia Drug Design Development and Therapy · 2023
    30. Congenital Adrenal Hyperplasia-Current Insights in Pathophysiology, Diagnostics, and Management. PubMed · 2022 · 188 citations