K6/ODC Transgenic Mice as a Sensitive Model for Carcinogen Identification

    July 2000 in “ Toxicology Letters ”
    Yan Chen, Louis C. Megosh, Susan K. Gilmour … Thomas G. O’Brien
    Studysummary This study found that the K6/ODC transgenic mouse model is highly sensitive to identifying genotoxic carcinogens, showing 100% concordance with traditional rodent bioassays.
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    Research cited in this study 2

    1. Ornithine Decarboxylase Overexpression Is a Sufficient Condition for Tumor Promotion in Mouse Skin PubMed · 1997
    2. Heterogeneity of Ornithine Decarboxylase Expression in 12-O-Tetradecanoylphorbol-13-Acetate-Treated Mouse Skin and in Epidermal Tumors Carcinogenesis · 1986