Promotion of Skin Carcinogenesis by Dimethylarsinic Acid in Keratin (K6)/ODC Transgenic Mice

The study investigated the effect of dimethylarsinic acid (DMA) on skin carcinogenesis in K6/ODC transgenic mice, which are more sensitive to carcinogens due to the overexpression of ornithine decarboxylase in hair follicle keratinocytes. Female C57BL/6J K6/ODC transgenic mice were treated with DMA after initiation with 7,12-dimethylbenz[α]anthracene (DMBA). The results showed that DMA significantly accelerated the induction of skin tumors, similar to the known tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), indicating that DMA had a promoting effect on skin tumorigenesis in these transgenic mice.