Short-Term Biomarkers of Cigarette Smoke Condensate Tumor Promoting Potential in Mouse Skin

    October 2005 in “ Toxicological Sciences ”
    Geoffrey M. Curtin, Margaret Hanausek, Zbigniew Wałaszek … Thomas J. Slaga
    Studysummary In this study, mouse skin exposed to cigarette smoke condensate exhibited increased epidermal thickness and ODC expression, with some changes persisting after exposure ended, suggesting potential for tumor promotion and measurement discrimination.
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    Research cited in this study 4

    1. Co-Operation Between Follicular Ornithine Decarboxylase and v-Ha-ras Induces Spontaneous Papillomas and Malignant Conversion in Transgenic Skin Carcinogenesis · 1998
    2. Ornithine Decarboxylase Overexpression Is a Sufficient Condition for Tumor Promotion in Mouse Skin PubMed · 1997
    3. Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles Differentiation · 1994
    4. Induction of Ornithine Decarboxylase in Specific Subpopulations of Murine Epidermal Cells Following Multiple Exposures to 12-O-Tetradecanoylphorbol-13-Acetate, Mezerein, and Ethyl Phenylpropriolate Carcinogenesis · 1992

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    1. Ornithine Decarboxylase Overexpression Is a Sufficient Condition for Tumor Promotion in Mouse Skin PubMed · 1997