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research Inhibition of Metastatic Squamous Cell Carcinoma Development in Protein Kinase C Epsilon Transgenic Mice by Alpha-Difluoromethylornithine with Hair Follicle Degeneration and Hair Loss

26 citations , June 2003 in “PubMed”

Alpha-difluoromethylornithine prevents cancer in mice but causes hair loss.

research Alpha-Difluoromethylornithine, a Polyamine Inhibitor: Its Potential Role in Controlling Hair Growth and in Cancer Treatment and Chemoprevention

9 citations , April 2006 in “International Journal of Dermatology”

DFMO may help control hair growth and treat cancer.

Increased Polyamine Concentrations in the Hair of Cancer Patients

research Increased Polyamine Concentrations in the Hair of Cancer Patients

14 citations , January 2001 in “Clinical chemistry”

Hair can be used to measure cancer-related chemicals noninvasively.

research Disturbed Keratinocyte Differentiation in Transgenic Mice and Organotypic Keratinocyte Cultures Due to Spermidine/Spermine N1-Acetyltransferase Overexpression

37 citations , February 2005 in “Journal of Investigative Dermatology”

Overexpression of SSAT causes hair loss and skin issues, but reducing putrescine can help.

research Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice

91 citations , July 2004 in “Journal of Biological Chemistry”

Overexpressing SSAT enzyme reduces prostate tumor growth in mice.

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community Thoughts on this topical? Has a combination going on but are they really heavy hitters

in Treatment 1 upvotes 1 month ago

Follicium XR™ is a topical treatment for hair loss containing RU58841, AHK-Cu, GHK-Cu Peptide, caffeine, D-Biotin, methylene blue, keratin, and spermidine. RU58841 is considered the most effective ingredient, but concerns exist about its stability in water.