Ornithine
Research
20 / 478 resultsresearch Ornithine Decarboxylase Overexpression Is a Sufficient Condition for Tumor Promotion in Mouse Skin
In this study, targeting ornithine decarboxylase overexpression to hair follicle keratinocytes in mice was sufficient to promote skin tumor development without additional tumor promoters.
research Co-Operation Between Follicular Ornithine Decarboxylase and v-Ha-ras Induces Spontaneous Papillomas and Malignant Conversion in Transgenic Skin
This study found that overexpression of ornithine decarboxylase and activated Ha-ras together led to a high rate of tumor development in a mouse model without additional carcinogens.
research Modulation of Murine Hair Follicle Function by Alterations in Ornithine Decarboxylase Activity
This study found that overexpression of a mutated ornithine decarboxylase transgene in mice led to complete hair loss, which could be prevented or reversed with an ODC inhibitor.
research A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis
This study found that overexpression of the enzyme ornithine decarboxylase in transgenic mice led to UVB-induced skin tumors, but this was prevented by the ODC inhibitor α-difluoromethylornithine.
research Ornithine Decarboxylase as a Target for Chemoprevention of Basal and Squamous Cell Carcinomas in Ptch1+/– Mice
In this study, overexpression of ornithine decarboxylase accelerated basal cell carcinoma in Ptch1+/– mice under UVB exposure, while its inhibition reduced tumor induction, suggesting potential chemoprevention strategies in humans.
research Ornithine Decarboxylase as a Target for Chemoprevention of Basal and Squamous Cell Carcinomas in Ptch1+/– Mice
This study found that inhibiting the enzyme ornithine decarboxylase (ODC) prevented UVB-induced basal cell carcinomas in a mouse model, suggesting ODC is a potential target for chemoprevention strategies.
research Ornithine Decarboxylase Expression Leads to Translocation and Activation of Protein Kinase CK2 In Vivo
This study suggests that polyamines regulate CK2 enzyme activity and its subcellular distribution, as demonstrated in mouse models and cell cultures with elevated levels of ornithine decarboxylase.
research Ornithine Decarboxylase Is Upregulated by the Androgen Receptor in Skeletal Muscle and Regulates Myoblast Proliferation
This study found that androgens increase Odc1 expression in skeletal muscle myoblasts, promoting proliferation and delaying differentiation.
research Heterogeneity of Ornithine Decarboxylase Expression in 12-O-Tetradecanoylphorbol-13-Acetate-Treated Mouse Skin and in Epidermal Tumors
This study found that TPA treatment transiently induces high levels of ODC in mouse epidermal cells, particularly around hair follicles, with localization reduced by retinoic acid or cycloheximide pretreatment.
research Ornithine Decarboxylase Activity in Relation to DNA Synthesis in Mouse Interfollicular Epidermis and Hair Follicles
research Ornithine Decarboxylase Expression in Cutaneous Papillomas in SENCAR Mice Is Associated with Altered Expression of Keratins 1 and 10
This study reported that high ornithine decarboxylase expression and decreased keratin K1 and K10 expression may serve as useful markers for early stages of tumor development in mouse skin.
research Conversion of C57Bl/6 Mice from a Tumor Promotion-Resistant to a Sensitive Phenotype by Enhanced Ornithine Decarboxylase Expression
This study in a transgenic mouse model found that repressing overexpression of ornithine decarboxylase reduced papilloma development, indicating its role in tumor promotion sensitivity.
research Induction of Ornithine Decarboxylase in Specific Subpopulations of Murine Epidermal Cells Following Multiple Exposures to 12-O-Tetradecanoylphorbol-13-Acetate, Mezerein, and Ethyl Phenylpropriolate
This study suggests that chronic treatment with TPA in mouse skin selectively expands a keratinocyte subpopulation hyperinducible for ODC, which may be a key target for neoplastic transformation.
research Dynamic Expression of Ornithine Decarboxylase in Hair Growth
This study found that ornithine decarboxylase expression is linked to cell proliferation and differentiation in hair follicle development and growth.
research Ornithine Decarboxylase Transgenic Mice as a Model for Human Atrichia with Papular Lesions
This study observed that overexpression of the enzyme ODC in transgenic mice caused hair loss and skin changes similar to human papular atrichia, suggesting that ODC might be involved in a critical hair follicle function pathway.
research Elevated Ornithine Decarboxylase Activity Promotes Skin Tumorigenesis by Stimulating the Recruitment of Bulge Stem Cells but Not via Toxic Polyamine Catabolic Metabolites
This study found that elevated epidermal ODC activity in transgenic mice promotes skin tumor development by recruiting bulge stem cells, rather than through reactive oxygen species generation by polyamine catabolic oxidases.
research A Simple In Vivo System for Studying Epithelialization, Hair Follicle Formation, and Invasion Using Primary Epidermal Cells from Wild-Type and Transgenic Ornithine Decarboxylase-Overexpressing Mouse Skin
This study demonstrated that the tracheal xenotransplant procedure is an effective technique for assessing the invasiveness of epidermal keratinocytes and studying factors affecting hair follicle formation.
research The Retarded Hair Growth Mutation in Mice Is an Allele of Ornithine Aminotransferase
This study discovered that a specific G to C mutation in the ornithine aminotransferase gene is linked to the retarded hair growth phenotype in mice and may serve as a model for human gyrate atrophy.
research Normalization of Hair Growth in Sparse Fur-Abnormal Skin and Hair (SPF-ASH) Mice by Introduction of the Rat Ornithine Transcarbamylase (OTC) Gene
This study found that introducing the recombinant rat OTC gene into SPF-ASH mice restored normal hair growth and metabolic function, improving symptoms associated with OTC deficiency.
research Induction of Ornithine Decarboxylase Activity in Hairless Rat Epidermis as a Pharmacological Model: Validation of the Animal Model
This study suggests that female hairless rats aged about 8 weeks offer the most consistent and reliable response in tests evaluating epidermal ornithine decarboxylase activity.