Analysis of Skin Graft Survival Using Green Fluorescent Protein Transgenic Mice

    January 2007 in “ Journal of medical investigation ”
    Shingo Matsuo, Akira Kurisaki, Hiromu Sugino, Ichiro Hashimoto, Hideki Nakanishi
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    Studysummary This study found that transplanting GFP transgenic tail skin onto wild-type mice leads to partial replacement of dermis, nerves, and blood vessels by recipient tissue after six months, while epidermis, hair follicles, and sebaceous glands persist from the graft. Our plain-language summary of this paper — not a Tressless recommendation.
    In this study, researchers used green fluorescent protein (GFP) transgenic mice to analyze the origin of cells in skin grafts. They transplanted dorsal and tail skin between GFP transgenic and wild-type mice. Due to severe immunorejection with full-thickness back skin, tail skin was used. Six months post-transplantation, immunohistochemical analysis showed that ectodermal tissues like the epidermis, hair follicles, and sebaceous glands survived, while other tissues such as the dermis, nerves, and blood vessels were partially replaced by recipient tissues. The study demonstrated that GFP transgenic mice are useful for studying cell origins in transplants.
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