Skin-Specific Transgenic Overexpression of Ovine β-Catenin in Mice

    January 2023 in “ Frontiers in Genetics ”
    Li Wang, Kai Cui, Guoying Hua … Xuemei Deng
    Studysummary This study found that overexpression of ovine β-catenin in transgenic mice increased hair follicle density by promoting the transition from catagen to anagen.
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    Research cited in this study 7

    1. Hair Follicle Stem Cells as a Skin-Organizing Signaling Center During Adult Homeostasis The EMBO Journal · 2021
    2. Transcriptome Analysis of Improved Wool Production in Skin-Specific Transgenic Sheep Overexpressing Ovine β-Catenin International journal of molecular sciences · 2019
    3. Identification of Skin-Expressed Genes Possibly Associated with Wool Growth Regulation of Aohan Fine Wool Sheep BMC Genetics · 2014
    4. Deciphering the Function of Canonical Wnt Signals in Development and Disease: Conditional Loss- and Gain-of-Function Mutations of β-Catenin in Mice Genes & Development · 2008
    5. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    6. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    7. The Secret Life of the Hair Follicle Trends in genetics · 1992