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research Skin-Specific Transgenic Overexpression of Ovine β-Catenin in Mice

2 citations, January 2023 in “Frontiers in Genetics”

In this study, researchers generated transgenic mice with skin-specific overexpression of ovine β-catenin to investigate its role in hair follicle development. The ovine β-catenin gene was successfully integrated and inherited across six generations, as confirmed by PCR and Southern blot tests. qRT-PCR and western blot analyses showed specific expression of β-catenin mRNA in the skin. Phenotypic analysis of the sixth generation revealed that overexpression of β-catenin increased hair follicle density by accelerating the catagen-to-anagen transition, indicating that ovine β-catenin can promote hair follicle development in mice, demonstrating domestication traits in animals.

research Increased Vibrissa Growth in Transgenic Mice Expressing Insulin-Like Growth Factor 1

33 citations, February 1999 in “The journal of investigative dermatology/Journal of investigative dermatology”

IGF-1 increases whisker growth in transgenic mice.

The Peptide AC 2 Isolated from Bacillus-Treated Trapa Japonica Fruit Extract Rescues DHT-Treated Human Dermal Papilla Cells and Mediates mTORC1 Signaling for Autophagy and Apoptosis Suppression

research The Peptide AC 2 Isolated from Bacillus-Treated Trapa Japonica Fruit Extract Rescues DHT-Treated Human Dermal Papilla Cells and Mediates mTORC1 Signaling for Autophagy and Apoptosis Suppression

9 citations, November 2019 in “Scientific reports”

The AC 2 peptide from Trapa japonica fruit helps protect hair cells and may treat hair loss.

research Reduction of Intrafollicular Apoptosis in Chemotherapy-Induced Alopecia by Topical Calcitriol Analogs

53 citations, October 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Topical calcitriol-analogs can reduce hair loss caused by chemotherapy.

Flavonoids in Safflower Extract Reduce Cisplatin-Induced Damage to Human Follicle Dermal Papilla Cells by Inhibiting DNA Damage and Rad17/Chk1/Cdc25C Signaling

research Flavonoids in Safflower Extract Reduce Cisplatin-Induced Damage to Human Follicle Dermal Papilla Cells by Inhibiting DNA Damage and Rad17/Chk1/Cdc25C Signaling

January 2023 in “Biocell”

Safflower extract helps protect hair follicle cells from damage caused by chemotherapy.

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Community Join

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community Doctor says i shouldn't take fin because its "hormonal"

in Finasteride/Dutasteride 105 upvotes 1 month ago

A user in Turkey was advised by a dermatologist to avoid finasteride due to its hormonal effects and was prescribed minoxidil, shampoo, and vitamins instead. The user is considering seeking another doctor's opinion or buying finasteride directly from a pharmacy.

community DNA Testing by Roots by Genetic Arts

in Research/Science 3 upvotes 6 months ago

A user shared their positive experience with Roots by GA, a company that creates personalized hair loss treatments based on DNA analysis, which confirmed their inability to tolerate finasteride. The user is satisfied with their progress 30 days after a hair transplant and the customized formula they received.

community Topical Melatonin for mild aga

in Chat 2 upvotes 6 months ago

The conversation is about an 18-year-old male considering topical finasteride for hair loss and asking about the effectiveness of topical melatonin for hair regrowth and density. No specific treatments were confirmed to be used.

community Trichotest results in… min not on my list! Just Fin/Dut, Zinc… and the insanely expensive latanoprost & prostaquinon.

in Technology 22 upvotes 2 years ago

Hair loss discussion includes treatments like hinoki tree oil and procyanidin b2. Experiences and effectiveness of these treatments are shared.

community Average tressless user after taking oral minoxidil

in Satire 1438 upvotes 1 year ago

The conversation is about hair loss and the use of minoxidil (Minoxidil) and finasteride (Fin) as treatments. The conclusion is that some users have seen success in maintaining their hair with minoxidil, but there are varying opinions on the effectiveness of the treatments.

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