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hormone commonly taken for sleep aid has some topical benefits for hair
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5 / 1000+ resultsresearch Skin-Specific Transgenic Overexpression of Ovine β-Catenin in Mice
In this study, researchers generated transgenic mice with skin-specific overexpression of ovine β-catenin to investigate its role in hair follicle development. The ovine β-catenin gene was successfully integrated and inherited across six generations, as confirmed by PCR and Southern blot tests. qRT-PCR and western blot analyses showed specific expression of β-catenin mRNA in the skin. Phenotypic analysis of the sixth generation revealed that overexpression of β-catenin increased hair follicle density by accelerating the catagen-to-anagen transition, indicating that ovine β-catenin can promote hair follicle development in mice, demonstrating domestication traits in animals.
research Transcriptome Analysis of Improved Wool Production in Skin-Specific Transgenic Sheep Overexpressing Ovine β-Catenin
Genetically modified sheep with more β-catenin grew more wool without changing the wool's length or thickness.
research Crosstalk Between Androgen and Wnt/β-Catenin Leads to Changes in Wool Density in FGF5-Knockout Sheep
Blocking the FGF5 gene in sheep leads to more fine wool and active hair follicles due to changes in certain cell signaling pathways.
research MiR-23b and MiR-133 Cotarget TGFβ2/NOTCH1 in Dermal Fibroblasts and Affect Hair Follicle Development in Sheep
Two microRNAs affect hair follicle development in sheep by targeting specific genes.
research Hair-Growth-Promoting Effects of the Fish Collagen Peptide in Human Dermal Papilla Cells and C57BL/6 Mice Modulating Wnt/Beta-Catenin and BMP Signaling Pathways
The study investigated the effects of fish collagen peptides (CP) on hair growth in human dermal papilla cells and C57BL/6 mice, focusing on the Wnt/β-catenin and BMP signaling pathways. CP significantly enhanced cell proliferation and hair regrowth, with the CP1000 group showing results comparable to finasteride. CP increased the expression of hair growth factors (IGF-1, VEGF, krt27, Gprc5d, Ki67) and decreased TGF-β1, a growth inhibitor. Protein analysis revealed that CP upregulated Wnt10b and β-catenin levels while downregulating BMP4 and BMP6 levels. The findings suggest that CP could be a promising nutraceutical for hair loss prevention and regrowth.
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5 / 854 resultscommunity An argument for why we should take topical Dutasteride seriously
Topical Dutasteride may halt hair loss and effectively treat androgenic alopecia. Combining low-dose oral Dutasteride with topical application could maximize regrowth and minimize side effects.
community Results after more than 1.5 years on Finasteride
A user shared their experience with finasteride for hair loss, noting it slowed but didn't stop their hair loss, and they quit after 1.5 years. Suggestions included trying dutasteride, adding minoxidil, and maintaining a healthy lifestyle.
community I feel like people here shrug off nutritional issues too quickly. Particularly for Retrograde Alopecia.
The user believes Retrograde Alopecia may be linked to vitamin imbalances, specifically from taking too much Vitamin E, A, Zinc, and Selenium, and suggests it could be a middle ground between Androgenic Alopecia and Telogen Effluvium. Treatments for hair loss mentioned include Androgen inhibitors and improving lifestyle factors like nutrition and sleep, with topical melatonin also recommended for Retrograde Alopecia.
community Taurine supplements work for hair growth?
The conversation discusses taurine supplements for hair growth, highlighting their potential to reduce DHT and improve hair health. A user comments that people often try alternatives to finasteride.
community Why isn’t anyone talking about this?
Hair cloning is being developed by companies like Kangstem Biotech and Stemson, with potential availability in a few years. Initial costs are expected to be high, but prices may decrease over time.