The Effect of Proteolytic Enzymes on Hair Follicles of Transgenic Mice Expressing the Lac Z-Protein in Cells of the Bulge Region

    July 1999 in “ JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology ”
    Evangelia Protopapa, H. Gaissert, Aristotelis Xenakis, S. Avramiotis, N. Stavrianeas, Constantin E. Sékeris, Johannes Schenkel, Ángel Alonso
    Image of study
    TLDR Proteolytic enzymes damage hair follicles by detaching stem cells.
    The study investigated the effects of proteolytic enzymes on hair follicles in transgenic mice expressing the lac-Z protein in bulge region cells, which are considered follicle stem cells. Chymotrypsin and papain were applied via iontophoresis, and trypsin was delivered in liposome form. The treatments caused significant degenerative effects on the hair follicles, including detachment of the inner root sheath, cystic dilation of the hair shaft, and the presence of epithelial cells within the lumen. These results suggested that the enzyme treatments impaired the function of hair follicle stem cells by detaching them from the bulge area.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    3 / 3 results

      community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

      in Research/Science  136 upvotes 7 months ago
      The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

      community Is GT20029 supposed to regrow hair as well?

      in Treatment  10 upvotes 1 year ago
      The user is considering switching from finasteride to dutasteride for hair loss. They are unsure if GT20029 can regrow hair, particularly on the temples. Another user mentions that regrowth on finasteride can take up to 2 years.

    Related Research

    1 / 1 results