Cartilage Oligomeric Matrix Protein Forms Part of the Connective Tissue of Normal Human Hair Follicles
February 2011
in “
Experimental dermatology
”
cartilage oligomeric matrix protein COMP connective tissue sheath CTS fibroblasts extracellular matrix ECM hair follicles telogen anagen catagen bulge area TGFβ2 TGFβ signaling hair cycle chondrodysplasia scleroderma connective tissue hair cycle phases growth phase resting phase regression phase transforming growth factor beta 2 TGF beta signaling hair abnormalities
Studysummary This study identifies cartilage oligomeric matrix protein (COMP) as a key extracellular matrix component in human hair follicle cycling, potentially regulated by TGFβ signaling, and suggests its importance in normal hair follicle biology.
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