72 citations
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June 2001 in “Journal of Investigative Dermatology” S100A4 and S100A6 proteins may activate stem cells for hair follicle regeneration and could be potential targets for hair loss treatments.
December 2023 in “Sains Malaysiana” The enzyme Rand protease works well for leather dehairing and its stability is important, with Leu75 playing a key role.
40 citations
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November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” S100A3 protein is crucial for hair shaft formation in mice.
26 citations
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June 2005 in “British Journal of Dermatology” Calretinin identifies the companion cell layer in human hair follicles.
22 citations
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September 2001 in “Journal of Investigative Dermatology” The study investigated the expression of calcium-binding proteins S100A8 and S100A9 in human hair follicles and found that these proteins were abundantly expressed in the medulla of the hair shaft, particularly during the anagen phase of hair growth. This suggested their role in the terminal differentiation of hair follicle cells. The expression patterns of S100A8 and S100A9 were distinct from other keratinocyte markers like K14, indicating a specific function in hair follicle biology rather than in regular interfollicular epidermis. The study highlighted the potential regulatory roles of these proteins in hair shaft formation and suggested further research to understand their functional relevance.