Transglutaminase 2 Deficiency Leads to Lipid Accumulation and Reduced Autophagy in SZ95 Sebocytes
TLDR Lack of TG2 increases fat storage and lowers cell cleanup in skin oil cells.
The study "1329 Transglutaminase 2 deficiency leads to lipid accumulation and reduced autophagy in SZ95 sebocytes" investigates the role of Transglutaminase 2 (TG2) in sebaceous gland biology. The researchers used TG2 knockout (KO) mice and a permanent TG2 KO SZ95 sebocyte cell line generated with the CRISPR/Cas9 method. The results showed that the absence of TG2 led to an accumulation of lipid droplets in higher amounts in sebocytes, which was associated with lower levels of autophagy markers such as ATG5, ATG7, and LC3II/I. The study suggests that TG2 may contribute to sebum production via the regulation of autophagy, indicating potential TG2-related regulatory processes as targets for interventions in dermatological disorders with altered sebum production.
