Effect of Free Long-Chain Fatty Acids on Anagen Induction: Metabolic or Inflammatory Aspect?

    March 2025 in “ International Journal of Molecular Sciences ”
    Xiao-wen Pan, Khava S. Vishnyakova, E. S. Chermnykh … Yegor E. Yegorov
    Studysummary This study observed that topical application of palmitate or oleate accelerated the onset of the hair growth phase in mice, whereas glycolysis end product lactate delayed it, suggesting metabolic regulation as a promising approach for influencing hair growth.
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    Research cited in this study 22

    1. Autophagy Induces Hair Follicle Stem Cell Activation and Hair Follicle Regeneration by Regulating Glycolysis 2024
    2. Deciphering the Molecular Mechanisms of Stem Cell Dynamics in Hair Follicle Regeneration 2024
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    4. LSD1 Interacting With HSP90 Promotes Skin Wound Healing by Inducing Metabolic Reprogramming of Hair Follicle Stem Cells Through the c-MYC/LDHA Axis ˜The œFASEB journal · 2023
    5. Consumption of Fish Oil High-Fat Diet Induces Murine Hair Loss via Epidermal Fatty Acid Binding Protein in Skin Macrophages Cell reports · 2022
    6. Human Hair Follicles Operate an Internal Cori Cycle and Modulate Their Growth via Glycogen Phosphorylase Scientific Reports · 2021
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    12. The Force Is Strong with This One: Metabolism Overpowers Stem Cell Fate Trends in cell biology · 2018
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    15. Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle Journal of Investigative Dermatology · 2017
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