Effect of Free Long-Chain Fatty Acids on Anagen Induction: Metabolic or Inflammatory Aspect?

March 2025 in “ International Journal of Molecular Sciences ”

Xiao-wen Pan, Khava S. Vishnyakova, E. S. Chermnykh, Maxim V. Jasko, Alexander D. Zhuravlev, S. Verkhova, Yegor S. Chegodaev, Mikhail А. Popov, Nikita G. Nikiforov, Yegor E. Yegorov

anagen phase free long-chain fatty acids palmitate oleate palmitic acid lactate monocytes fibroblasts keratinocytes metabolic regulation inflammatory response

Studysummary This study observed that topical application of palmitate or oleate accelerated the onset of the hair growth phase in mice, whereas glycolysis end product lactate delayed it, suggesting metabolic regulation as a promising approach for influencing hair growth.

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