Transglutaminase-3, an Esophageal Cancer-Related Gene

    January 2000 in “ International Journal of Cancer ”
    Baosheng Chen, Ming‐Rong Wang, Xin Xu, Yan Cai, Zhixiong Xu, Yaling Han, Min Wu
    TLDR Transglutaminase-3 is often reduced in esophageal cancer.
    The study investigated the role of Transglutaminase-3 (TGase-3) in human esophageal cancer. Researchers conducted mRNA differential display on 3 pairs of esophageal cancer tissues and matched normal mucosa, identifying a consistent down-regulation of TGase-3 in cancerous tissues. This was confirmed through Northern blot and dot blot analyses of 14 samples, and RT-PCR showed decreased TGase-3 expression in 35 out of 38 tumors compared to normal mucosa. Overall, 49 out of 52 (94.2%) esophageal tumors exhibited down-regulation of TGase-3, suggesting that its altered expression was a common event in the development of esophageal cancer.
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