Transglutaminase-3, an Esophageal Cancer-Related Gene

    January 2000 in “ International Journal of Cancer ”
    Baosheng Chen, Ming‐Rong Wang, Xin Xu, Yan Cai, Zhixiong Xu, Yaling Han, Min Wu
    TLDR Transglutaminase-3 is often reduced in esophageal cancer.
    The study investigated the role of Transglutaminase-3 (TGase-3) in human esophageal cancer, revealing that TGase-3 expression was significantly down-regulated in cancerous tissues compared to normal tissues. Using mRNA differential display, Northern blot, dot blot analyses, and RT-PCR, researchers found that TGase-3 expression was lost in 3 esophageal carcinoma cell lines and decreased in 35 out of 38 tumors. Overall, 49 out of 52 (94.2%) esophageal tumors showed down-regulation of TGase-3, suggesting that this alteration was a common event in the development of esophageal cancer.
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