Quantitative Analysis of Hair Luster in a Novel Ultraviolet-Irradiated Mouse Model

February 2024 in “ International journal of molecular sciences ”

Kyung Bae Chung, Young In Lee, Yoo Jin Kim, Hyeon Ah, Jangmi Suk, Il‐Won Jung, Doyoung Kim, Ju Hee Lee

UVB irradiation hair luster Investigator’s Global Assessment pixel-based gloss assessment oral minoxidil gene expression profiling keratinization keratinization-related genes UVB IGA minoxidil

TLDR UV exposure reduced hair shine in mice, but minoxidil helped restore it.

This study introduces a novel UV-irradiated mouse model to simulate hair luster loss and evaluate treatments. UVB irradiation at 60 mJ/cm² significantly reduced hair luster, measured by both the Investigator’s Global Assessment (IGA) scale and pixel-based gloss assessment. Oral minoxidil treatment effectively reversed this loss, improving hair luster in both UV-irradiated and non-irradiated groups. Gene expression profiling indicated that UV irradiation upregulated keratinization-related genes, suggesting abnormal keratinization contributes to hair luster loss. This model is valuable for testing hair care treatments and understanding hair health.

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