Defective Maintenance of Hair Follicle Stem Cells Through COL17A1 Loss Orchestrates the Hair Follicle Aging Program

September 2017 in “ Journal of Investigative Dermatology ”

Hiroyuki Matsumura, Yasuaki Mohri, Thiennga K. Nguyen, H. Morinaga, Makoto Fukuda, Mayumi Ito, Sotaro Kurata, Jan H.J. Hoeijmakers, Emi K. Nishimura

hair follicle stem cells COL17A1 type XVII collagen DNA damage response epidermal differentiation hair follicle miniaturization

TLDR Loss of COL17A1 causes hair follicle stem cells to age and leads to hair loss.

The study investigated the mechanisms behind hair follicle aging and hair loss, focusing on hair follicle stem cells (HFSCs) and the role of type XVII collagen (COL17A1). Researchers found that DNA damage response in murine HFSCs led to the degradation of COL17A1, crucial for HFSC maintenance. This degradation initiated an epidermal differentiation program, causing HFSCs to migrate and be shed from the epidermis, leading to irreversible hair loss. Similar processes were observed in Col17a1-deficient and progeric mouse models. In humans, aging scalps showed hair follicle miniaturization and impaired COL17A1 expression. Notably, maintaining COL17A1 expression in aging mice's HFSCs significantly rescued the aging program, suggesting that modulating COL17A1 expression could control tissue aging in mammalian stem cells.

View this study on jidonline.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Physio-metabolic method (antiandrogen, minoxidil, leg training and cold)

in Treatments 309 upvotes 1 year ago

The method combines finasteride, minoxidil, intense leg exercises, and cold exposure to treat androgenetic alopecia. It aims to boost metabolism and reduce androgenic effects, enhancing hair growth.

community How does dutasteride regrowth work?

in Finasteride/Dutasteride 7 upvotes 1 year ago

A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

community "Hair Follicle Stem Cells are quiescent 99% of the time and permanently reside in the hair follicle"

in Research/Science 1388 upvotes 3 months ago

Hair follicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.

community New Study: PP405, developed by Pelage Pharmaceuticals, can reactivate dormant hair follicle stem cells and stimulate natural hair growth by 20%

in Research/Science 835 upvotes 2 months ago

PP405, developed by Pelage Pharmaceuticals, can reactivate dormant hair follicle stem cells and increase hair growth by 20% in eight weeks, unlike minoxidil or finasteride. However, skepticism remains about its effectiveness and availability, with concerns about funding and the timeline for broader access.

community redensyl - follicle stem cell activator any experiences?

in Question 8 upvotes 8 years ago

A Swiss product called Redensyl, which is supposed to target hair follicle stem cells and has recently been marketed in Europe. The post inquires if anyone has had any experience with the product.

Related Research

8 / 8 results

research Hair Loss

August 2021 in “Pharmacy Today”

The document's conclusion about hair loss cannot be determined.

research Hair Loss: Causes and Pathology

June 2021 in “International Journal of Research in Medical Sciences & Technology”

Hair loss has many causes and needs specific treatments.

research Diffuse Hair Loss

June 2021 in “Elsevier eBooks”

The document's conclusion cannot be summarized because it is not readable or understandable.

research The Effect of Flavonoids on Regenerated Hair Follicles with Pigmentation

April 2017 in “Journal of Dermatological Science”

Certain flavonoids can improve the growth of pigmented hair in mice.

research A Review on Hair Loss and Damage

January 2016

The article concludes that understanding the causes of hair loss and using continuous treatments like minoxidil and finasteride can help manage it, despite potential side effects.

research Protection Against Chemotherapy-Induced Alopecia: Targeting ATP-Binding Cassette Transporters in the Hair Follicle

24 citations , November 2013 in “Trends in pharmacological sciences”

Increasing ABC transporters in hair follicles may prevent chemotherapy-induced hair loss.

research Pathobiology of Chemotherapy-Induced Hair Loss

218 citations , January 2013 in “The Lancet Oncology”

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

research Towards a Molecular Understanding of Hair Loss and Its Treatment

236 citations , July 2001 in “Trends in Molecular Medicine”

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.