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    Glossary COL17A1

    gene encoding a protein crucial for skin and hair integrity

    COL17A1 is a gene that encodes for a protein called collagen type XVII, alpha 1. This protein is crucial for the structural integrity of the skin, as it helps anchor the outer layer of the skin (epidermis) to the underlying layer (dermis). Mutations in the COL17A1 gene can lead to skin disorders and hair loss conditions, such as epidermolysis bullosa and certain types of alopecia.

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    Research 30 of 721

    1. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis Science · 2016 · 242 citations
    2. Expression of anti-aging type-XVII collagen (COL17A1/BP180) in hair follicle-associated pluripotent (HAP) stem cells during differentiation Tissue & Cell · 2019 · 11 citations
    3. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis Journal of Dermatological Science · 2017 · 8 citations
    4. 244 Defective maintenance of hair follicle stem cells through COL17A1 loss orchestrates the hair follicle aging program Journal of Investigative Dermatology · 2017
    5. Restoration of Hair Luster via Novel Biomarker COL7A1 by Minoxidil, Caffeine, and Biotin Current Issues in Molecular Biology · 2025
    6. 688 Precise and efficient editing of the COL7A1 gene in RDEB derived iPSCs with CRISPR/Cas9 and prime editing Journal of Investigative Dermatology · 2024
    7. Generating LacZ-reporter transgenic mice to identify α1 (XIX) Collagen (Col19a1) expression in Dermal Papilla Cells Benha Veterinary Medical Journal · 2016
    8. Three Novel Homozygous Point Mutations and a New Polymorphism in the COL17A1 Gene: Relation to Biological and Clinical Phenotypes of Junctional Epidermolysis Bullosa The American Journal of Human Genetics · 1997 · 80 citations
    9. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011 · 283 citations
    10. Foxc1 reinforces quiescence in self-renewing hair follicle stem cells Science · 2016 · 142 citations
    11. Type XVII collagen coordinates proliferation in the interfollicular epidermis eLife · 2017 · 124 citations
    12. Signature selection analysis reveals candidate genes associated with production traits in Iranian sheep breeds BMC Veterinary Research · 2021 · 55 citations
    13. Generalized atrophic benign epidermolysis bullosa. PubMed · 1997 · 51 citations
    14. The Genetics of Human Skin Disease Cold Spring Harbor Perspectives in Medicine · 2014 · 24 citations
    15. Comprehensive RNA sequencing in primary murine keratinocytes and fibroblasts identifies novel biomarkers and provides potential therapeutic targets for skin-related diseases Cellular & Molecular Biology Letters · 2021 · 17 citations
    16. TGF-β2 and collagen play pivotal roles in the spheroid formation and anti-aging of human dermal papilla cells Aging · 2021 · 11 citations
    17. Novel complex of cosmetic ingredients with promising action in preventing hair loss and follicular aging through mechanism involving enrichment of <i>WNT</i>/signaling, mitochondrial activity, and stem cells maintenance Journal of Cosmetic Dermatology · 2020 · 8 citations
    18. Focal palmoplantar callosities in non-Herlitz junctional epidermolysis bullosa Journal of the American Academy of Dermatology · 2005 · 5 citations
    19. Read-Through for Nonsense Mutations in Type XVII Collagen‒Deficient Junctional Epidermolysis Bullosa 2022 · 5 citations
    20. Niche work when you can get it: collagen XVII and the melanocyte stem cell Pigment Cell & Melanoma Research · 2011 · 2 citations
    21. Dab2 (Disabled-2), an adaptor protein, regulates self-renewal of hair follicle stem cells Communications Biology · 2024 · 1 citations
    22. Keratinocyte Stem Cells: Role in Aging IntechOpen eBooks · 2022 · 1 citations
    23. Case of non-Herlitz junctional epidermolysis bullosa with<i>COL17A1</i>mutation The Journal of Dermatology · 2015 · 1 citations
    24. Mesenchymal stem cell-derived exosomes promote scalp rejuvenation through type XVII collagen regulation via the miR-21-5p/DKK2/Wnt pathway Frontiers in Cell and Developmental Biology · 2026
    25. 464 Spatial transcriptomics links gene expression profiles to functional and structural traits of darkly pigmented skin Journal of Investigative Dermatology · 2025
    26. 583 Induction of type 17 collagen decreases ultraviolet b-induced cellular senescence in human htert/ker-ct keratinocytes 2022
    27. Quiescent and aging hair follicle stem cells Science · 2016
    28. Australasian Society for Dermatology Research Meeting, May 2006 Journal of Investigative Dermatology · 2007
    29. Scarring Alopecia in Localized Dystrophic Epidermolysis Bullosa: A Case Report and a Scoping Review Cureus · 2025
    30. Inherited Epidermolysis Bullosa: A Clinical Case Medical journal of clinical trials & case studies · 2020