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GlossaryCollagen XVII (BP180)

protein crucial for skin structure and integrity

Collagen XVII, also known as COL17 or BP180, is a type of protein found in the skin that plays a crucial role in maintaining the structure and integrity of the skin's basement membrane, which separates the outer layer of skin from the underlying layers. It is essential for skin adhesion and wound healing, and its dysfunction can lead to skin blistering diseases such as bullous pemphigoid.

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Expression of Anti-Aging Type-XVII Collagen (COL17A1/BP180) in Hair Follicle-Associated Pluripotent (HAP) Stem Cells During Differentiation

research Expression of Anti-Aging Type-XVII Collagen (COL17A1/BP180) in Hair Follicle-Associated Pluripotent (HAP) Stem Cells During Differentiation

11 citations, June 2019 in “Tissue & Cell”

Hair stem cells produce a protein called COL17A1 that plays a key role in their development and is linked to hair thinning and baldness.

research SnapshotDx Quiz: May 2020 Study on BIVV009 in Bullous Pemphigoid

May 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

BIVV009 is a safe treatment for bullous pemphigoid that reduces C3 deposition without harmful side effects.

Three-Dimensional Imaging of Tight Junction Network Across Multiple Layers of Human Epidermis by Array Tomography Using Backscattered Electron-Mode Scanning Electron Microscopy

research Three-Dimensional Imaging of Tight Junction Network Across Multiple Layers of Human Epidermis by Array Tomography Using Backscattered Electron-Mode Scanning Electron Microscopy

August 2019 in “Journal of Investigative Dermatology”

The study found that tight junctions reach the top layer of the skin's stratum granulosum, not just the second top layer as previously thought.

research Fine Mapping of the Human AR/EDA2R Locus in Androgenetic Alopecia

28 citations, April 2010 in “British Journal of Dermatology”

Genetic marker rs12558842 strongly linked to male hair loss.

research Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis

242 citations, February 2016 in “Science”

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

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