TLDR 4-Aminopyridine improves skin wound healing and tissue regeneration by increasing cell growth and promoting nerve repair.
The study conducted on 5 mice per group found that 4-aminopyridine (4-AP) significantly enhances skin wound healing and tissue regeneration. The treatment led to faster wound closure, increased keratinocyte number, and epithelial stem-cell markers in healing wounds. It also increased fibroblast and myofibroblast numbers and levels of transforming growth factor-β. Additionally, 4-AP promoted division reinnervation, increased the number of Schwann cells, and enhanced the expression of markers of an early SC differentiation state. The study also found that 4-AP enhances the expression of transcription factors, neurotrophic factors, and neuropeptides associated with reinnervation. In vitro, 4-AP also accelerated keratinocyte wound closure.
77 citations,
July 2020 in “Cell” Muscles and nerves that cause goosebumps also help control hair growth.
128 citations,
August 2015 in “Cell Stem Cell” Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.
85 citations,
September 2013 in “International Journal of Molecular Sciences” Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.
829 citations,
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July 2022 in “Journal of Investigative Dermatology” Lef1 is essential for normal skin, hair growth, and healing wounds in mice.
July 2022 in “Biomedicines” 4-Aminopyridine improves skin wound healing and tissue regeneration by increasing cell growth and promoting nerve repair.
176 citations,
June 2019 in “Cells” Different fibroblasts play key roles in skin healing and scarring.
Dermal stem cells help regenerate hair follicles and heal skin wounds.
359 citations,
January 2015 in “Cold Spring Harbor Perspectives in Medicine” Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.
