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Research

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research The human type I keratin gene family: Characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain

70 citations , December 2004 in “Differentiation”

This study identifies six novel keratin genes from the chromosome 17q21.2 region, suggesting their association with hair follicles, while all 27 keratin genes in the domain have been characterized transcriptionally.

research 604 DNA dioxygenases TET regulate keratin gene expression and enhancer networks within lineage-specific gene loci during epidermal and hair follicle-specific keratinocyte differentiation

April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, researchers found that the deletion of Tet2/3 enzymes in mice led to changes in skin development and hair follicle differentiation, ultimately causing hair loss and altered gene expression.

research Hair Keratins and Hair Follicle–Specific Epithelial Keratins

31 citations , January 2004 in “Methods in cell biology”

Hair and follicle keratins differ in structure and expression, especially in cysteine content.

research The Enrichment of Specific Hair Follicle-Associated Cell Populations in Plucked Hairs Offers an Opportunity to Study Gene Expression Underlying Hair Traits

2 citations , December 2022 in “International journal of molecular sciences”

This study compared RNA-seq results from horse plucked-hair and skin-biopsy samples, finding that plucked hairs were enriched with hair-follicle keratinocytes, while biopsies showed enrichment for other cell types.

research Isolation and Characterization of a Novel Hair Follicle–Specific Gene, Hacl-1

25 citations , May 1994 in “Journal of Investigative Dermatology”

This study identified a novel gene, hacl-1, that is specifically expressed in the hair follicles of ICR mouse skin and is associated with their active state.

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Community Join

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community Keratin microspheres - breakthrough

14 upvotes 2 years ago

A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

community Mature hairlines in general and defining them

13 upvotes 5 years ago

A "mature hairline" is subjective and may not indicate future stability. Finasteride and minoxidil are suggested treatments for hair loss.

community Dutasteride or treatment and TRT/PEDs

1 upvotes 1 month ago

A user experienced hair thinning after using tamoxifen and bupropion and is now using topical dutasteride, alfatradiol, melatonin, adenosine, and specific shampoos for improvement. They are considering using steroids and are seeking advice on whether combining oral dutasteride with TRT/PEDs would affect hair health, with mixed opinions on the impact of testosterone and DHT on hair loss.

community What else is good. Besides the big 3.

in Chat 35 upvotes 1 year ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community Anyone here found a shampoo that actually helps with hair thinning?

68 upvotes 1 year ago

Cosmetics Hut Hair Strengthening Shampoo with Biotin Peppermint Platyclaudus is popular for reducing hair shedding. Other treatments mentioned include Minoxidil, finasteride, ketoconazole shampoo, and biotin supplements.

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Learn

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learn Hair Transplant

Surgery that moves hair follicles from the back of the scalp to thinning areas

learn Sulforaphane

How often should sulforaphane-based products be used for hair loss prevention? No human trial has tested sulforaphane for hair loss prevention, so there is no established usage frequency. Oral supplements are taken daily in research on unrelated conditions and the hair-specific evidence is limited to cell, mouse and isolated-follicle studies, so any schedule is extrapolation rather than a dosing guideline.

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Adenosine

Molecule the body uses for energy, used as a cosmetic hair-lotion ingredient

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Clinics

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All 14 clinic results →

Experts

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas