Dutasteride or treatment and TRT/PEDs
    8/7/2026

    From the encyclopedia
    Dutasteride β†’

    Heavy duty finasteride that comes with higher risks

    Alfatradiol β†’

    a synthetic estrogen used topically as an anti-androgen

    Melatonin β†’

    hormone commonly taken for sleep aid has some topical benefits for hair

    At a glance
    In this question or advice post, the primary subjects mentioned are
    πŸ’§ Dutasteride (topical) 0.1% EOD 3 weeks
    πŸ’§ Alfatradiol (topical) 0.1% EOD
    πŸ’§ Melatonin (topical) 1% EOD
    πŸ’§ Adenosine (topical) 1% EOD
    πŸ’§ Keto shampoo (topical)
    πŸ’§ Piroctane olamine shampoo (topical)
    πŸ’§ Microneedling (topical) once a week
    the tone is 😐 neutral with some improvements results.

    Other terms

    A user experienced hair thinning after using tamoxifen and bupropion and is now using topical dutasteride, alfatradiol, melatonin, adenosine, and specific shampoos for improvement. They are considering using steroids and are seeking advice on whether combining oral dutasteride with TRT/PEDs would affect hair health, with mixed opinions on the impact of testosterone and DHT on hair loss.
    View this post in the Community β†’

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       25 upvotes 2 years ago
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    Related Research

    6 / 6 results
      Interventions for Female Pattern Hair Loss

      research Interventions for female pattern hair loss

      21 citations , May 2016 in “The Cochrane library”
      This review found that while topical minoxidil is effective for treating female pattern hair loss, finasteride showed no more effectiveness than placebo, and low-level laser therapy increased hair count but with inconsistent results.
      Androgenetic Alopecia: An Evidence-Based Treatment Update

      research Androgenetic Alopecia: An Evidence-Based Treatment Update

      151 citations , May 2014 in “American Journal of Clinical Dermatology”
      This review concluded that oral finasteride for men and topical minoxidil for both genders have the most evidence supporting their effectiveness and safety for treating androgenetic alopecia.
      Interventions for Female Pattern Hair Loss

      research Interventions for female pattern hair loss

      35 citations , May 2012 in “Cochrane Database of Systematic Reviews”
      This review found evidence supporting the effectiveness and safety of topical minoxidil for treating female pattern hair loss, though many included studies were at high risk of bias.
      Androgenetic Alopecia in Men: An Update on Genetics

      research Androgenetic Alopecia in Men: An Update On Genetics

      May 2024 in “Indian Journal of Dermatology”
      In this review, an association was reported between early-onset androgenetic alopecia and several health conditions like obesity and cardiovascular disease, with genetic and therapeutic research ongoing to improve treatment.