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    Thyroxine (T4) May Promote Re-Epithelialization and Angiogenesis in Wounded Human Skin Ex Vivo

    March 2019 in “ PLoS ONE ”
    Guo-You Zhang, Ewan A. Langan, N. Meier … Ralf Paus
    Studysummary This study suggests that Thyroxine (T4) may promote key features of human skin wound healing, such as re-epithelialization and angiogenesis, in an ex vivo model.
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    Research cited in this study 21

    1. Olfactory Receptor OR2AT4 Regulates Human Hair Growth Nature Communications · 2018
    2. Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles PLOS Biology · 2018
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    7. The Thyroid Hormone Analogue KB2115 (Eprotirome) Prolongs Human Hair Growth (Anagen) Ex Vivo Journal of Investigative Dermatology · 2016
    8. Reflections on How Wound Healing-Promoting Effects of the Hair Follicle Can Be Translated into Clinical Practice Experimental Dermatology · 2014
    9. Thyrotropin-Releasing Hormone Promotes Wound Re-Epithelialisation in Frog and Human Skin PLOS ONE · 2013
    10. Hypothalamic–Pituitary–Thyroid Axis Hormones Stimulate Mitochondrial Function and Biogenesis in Human Hair Follicles Journal of Investigative Dermatology · 2013
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    12. Thyroid-Stimulating Hormone: A Novel, Locally Produced Modulator of Human Epidermal Functions, Regulated by Thyrotropin-Releasing Hormone and Thyroid Hormones Endocrinology · 2010
    13. Exploring the Thyroid-Skin Connection: Concepts, Questions, and Clinical Relevance Journal of Investigative Dermatology · 2009
    14. Human Female Hair Follicles Are a Direct, Nonclassical Target for Thyroid-Stimulating Hormone Journal of Investigative Dermatology · 2008
    15. Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation The Journal of Clinical Endocrinology & Metabolism · 2008
    16. Dissecting the Impact of Chemotherapy on the Human Hair Follicle ˜The œAmerican journal of pathology · 2007
    17. Human Hair Follicles Are an Extrarenal Source and a Nonhematopoietic Target of Erythropoietin ˜The œFASEB journal · 2007
    18. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
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