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Sorafenib Stimulates Human Skin Type Mast Cell Degranulation and Maturation

August 2017 in “ Journal of dermatological science ”

Yukari Mizukami, Koji Sugawara, Yukimi Kira, Daisuke Tsuruta

sorafenib mast cells degranulation PI3K signaling stem cell factor SCF skin reactions

TLDR Sorafenib causes skin reactions by increasing the number and activity of skin mast cells.

The study investigated the effects of sorafenib on skin-type mast cells (MCs) and found that it significantly increased the number and degranulation of MCs in human skin samples, without affecting their proliferation and apoptosis. This indicated that sorafenib stimulated MC maturation from resident precursors through PI3K signaling and increased stem cell factor (SCF) expression. The findings suggested that targeting PI3K signaling or SCF could be potential strategies for managing sorafenib-induced skin reactions.

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Research cited in this study

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research Patient-Level Adverse Event Patterns in a Single-Institution Study of the Multi-Kinase Inhibitor Sorafenib

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research Endocannabinoids Limit Excessive Mast Cell Maturation And Activation In Human Skin

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Endocannabinoids help control mast cell activity in human skin.

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