Sorafenib Stimulates Human Skin Type Mast Cell Degranulation and Maturation

    August 2017 in “ Journal of dermatological science ”
    Yukari Mizukami, Koji Sugawara, Yukimi Kira, Daisuke Tsuruta
    Studysummary This study found that sorafenib increased mast cell number and degranulation in skin, suggesting PI3K signaling and SCF production may underlie its adverse cutaneous reactions.
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    Research cited in this study 3

    1. Patient-Level Adverse Event Patterns in a Single-Institution Study of the Multi-Kinase Inhibitor Sorafenib Clinical and translational science · 2016
    2. Endocannabinoids Limit Excessive Mast Cell Maturation And Activation In Human Skin Journal of Allergy and Clinical Immunology · 2012
    3. Hand-Foot and Stump Syndrome Due to Sorafenib Journal of Clinical Oncology · 2007