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GlossaryDegranulation

release of granules from immune cells during immune responses

Degranulation is a process where certain cells, like mast cells and basophils, release granules containing chemicals such as histamine and cytokines into the surrounding tissue. This release plays a crucial role in immune responses, including inflammation and allergic reactions, by signaling other immune cells to the site of infection or injury.

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research Sorafenib Stimulates Human Skin Type Mast Cell Degranulation and Maturation

7 citations, August 2017 in “Journal of dermatological science”

Sorafenib causes skin reactions by increasing the number and activity of skin mast cells.

research Presence of Mast Cells and Mast Cell Degranulation in Scalp Biopsies of Telogen Effluvium

9 citations, January 2017 in “International Journal of Trichology”

The study suggests that mast cells might be involved in the hair loss condition telogen effluvium and could be a target for treatment.

Nuclear Factor (Erythroid-Derived 2)-Like-2 Pathway Modulates Substance P–Induced Human Mast Cell Activation and Degranulation in the Hair Follicle

research Nuclear Factor (Erythroid-Derived 2)-Like-2 Pathway Modulates Substance P–Induced Human Mast Cell Activation and Degranulation in the Hair Follicle

8 citations, May 2018 in “The Journal of Allergy and Clinical Immunology”

Activating the Nrf2 pathway reduces inflammation and cell activation in human hair follicles, suggesting a potential treatment for certain hair loss conditions.

research Profiling the Response of Human Hair Follicles to Ultraviolet Radiation

53 citations, January 2009 in “Journal of Investigative Dermatology”

UVB radiation harms hair growth and health, causing cell death and other changes in human hair follicles.

The Pathological Changes and Polymorphonuclear and Mast Cell Responses in the Skin of Specific Pathogen-Free Lambs Following Primary and Secondary Challenge with Orf Virus

research The Pathological Changes and Polymorphonuclear and Mast Cell Responses in the Skin of Specific Pathogen-Free Lambs Following Primary and Secondary Challenge with Orf Virus

18 citations, September 1990 in “Veterinary Dermatology”

Lambs' skin showed similar but more severe responses to a second orf virus infection, involving immune cells and new skin formation.

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