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GlossaryMast Cell Degranulation (Mast Cell Activation)

cells release histamine and other chemicals causing inflammation

Mast Cell Degranulation, also known as Mast Cell Activation, is a process where mast cells release granules containing histamine, cytokines, and other inflammatory mediators into the surrounding tissue. This release can trigger allergic reactions, inflammation, and other immune responses, playing a crucial role in conditions like asthma, eczema, and anaphylaxis.

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Nuclear Factor (Erythroid-Derived 2)-Like-2 Pathway Modulates Substance P–Induced Human Mast Cell Activation and Degranulation in the Hair Follicle

research Nuclear Factor (Erythroid-Derived 2)-Like-2 Pathway Modulates Substance P–Induced Human Mast Cell Activation and Degranulation in the Hair Follicle

8 citations, May 2018 in “The Journal of Allergy and Clinical Immunology”

Activating the Nrf2 pathway reduces inflammation and cell activation in human hair follicles, suggesting a potential treatment for certain hair loss conditions.

research Mast Cell Deficient and Neurokinin-1 Receptor Knockout Mice Are Protected from Stress-Induced Hair Growth Inhibition

76 citations, March 2005 in “Journal of Molecular Medicine”

Certain mice without specific receptors or mast cells don't lose hair from stress.

research Frontal Fibrosing Alopecia Is Associated With Dysregulation of Cholesterol Biosynthesis Pathways, Fibrosis, and Mast Cells

April 2019 in “Journal of Investigative Dermatology”

Frontal Fibrosing Alopecia involves disrupted cholesterol pathways, fibrosis, and increased mast cells.

research Pathophysiology of Behçet's Disease

34 citations, October 2011 in “Pathology Research International”

Behçet's Disease may be caused by genetic and environmental factors leading to abnormal immune responses, and stress management and new treatments could improve patient outcomes.

research Alopecia Areata: Genetic and Immunological Insights

1 citations, January 2017 in “Springer eBooks”

Understanding the immune-related causes of Alopecia Areata has led to potential treatments like JAK inhibitors.

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community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 100 upvotes 5 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community Can we once and for all clarify whether tretinoin helps or hurts hair?

in Treatment 39 upvotes 4 years ago

Tretinoin's effect on hair loss is debated; some say it improves minoxidil's effectiveness, while others claim it causes hair loss. Treatments discussed include tretinoin, minoxidil, finasteride, RU58841, and dermarolling.

community Trying to understand finasteride side effects and post finasteride syndrome

in Finasteride/Dutasteride 69 upvotes 4 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community I’m 14 years old and I’m losing more hair than my dad. I’ve gone to the doctor 2 times because of this and I’ve received no help. I’m starting to feel like It’s worthless and my hairs gonna look like this forever. I don’t know how anyone could help me but it’s always worth a shot.

in Treatment 4 years ago

A 14 year old who is experiencing hair loss and has not received any help from the doctor, with advice being given to try different doctors, get tested for underlying conditions and intolerances, buzz it short as an option and treatments that could slow down or reverse the hair loss such as minoxidil, finasteride, RU58841 and addressing the cause of the hair loss.

community What are your unpopular opinions on hair loss and its treatments?

in Chat 59 upvotes 6 months ago

Hair loss treatments like finasteride, minoxidil, and hair transplants are more accessible and effective now. Concerns about side effects and skepticism about new treatments like hair cloning and GT20029 remain.

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