Studysummary This article reviews potential factors influencing Behçet's disease, like increased neutrophil functions, immunological changes, stress, and hormonal alterations, but it presents no new clinical results. Our plain-language summary of this paper — not a Tressless recommendation.
The 2012 document reviews the complex pathophysiology of Behçet's Disease (BD), a chronic inflammatory condition with symptoms like oral-genital ulcers and uveitis. It suggests that BD may be caused by a combination of genetic susceptibility and environmental factors, leading to abnormal immune responses, including increased neutrophil functions and T lymphocyte abnormalities. The review also discusses the role of various factors in BD's pathogenesis, such as cytokines, oxidative stress, endothelial dysfunction, and hormonal influences. It notes that psychological stress and quality of life are significant in BD, and psychological interventions could be beneficial. Emerging pharmacological treatments targeting mast-cell activation are mentioned, and the potential of nonenzymatic antioxidants and trace elements in treating BD is highlighted. The document concludes that understanding the neuroimmunology of stress responses through the skin could provide insights into BD treatment.
29 citations
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February 2011 in “PloS one” This study found that blocking corticotropin-releasing factor receptors with astressin-B promoted hair regrowth and prevented alopecia in a mouse model of stress-induced hair loss.
98 citations
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December 2008 in “Journal of Investigative Dermatology” This review discusses the possible impacts of prolactin on skin conditions like psoriasis, alopecia, and stress-related dermatoses, emphasizing the need for further research to explore its therapeutic potential.
375 citations
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July 2006 in “Journal of Investigative Dermatology” This review discusses the brain-skin connection, the skin's role in stress response, and highlights unmet challenges in understanding stress-induced skin inflammation but reports no new experimental findings.
76 citations
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March 2005 in “Journal of Molecular Medicine” This study found that premature hair loss due to stress does not occur in NK-1 receptor knockout or mast cell deficient mice, suggesting a key role for neurokinin substance P and mast cell interaction in stress-related hair follicle changes.
125 citations
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September 2001 in “The FASEB Journal” This study demonstrated that stress inhibited hair growth in mice, likely through substance P-dependent activation of immune cells, highlighting a brain-hair follicle connection.
41 citations
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September 1991 in “Medical hypotheses” This article reviews the potential role of prolactin as a neuroendocrine modulator in skin biology and pathology, discussing its relevance for conditions such as psoriasis and hair growth, but reports no new clinical findings.
