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research Generalized pruritus in primary sclerosing cholangitis: implications of histamine release by lysophosphatidic acid

5 citations , June 2015 in “British Journal of Dermatology”

This article discusses the role of lysophosphatidic acid-induced histamine release in generalized pruritus among patients with primary sclerosing cholangitis and reports no new clinical results.

research SnapshotDx Quiz: February 2018

January 2018 in “Journal of Investigative Dermatology”

This quiz article provides a series of dermatological diagnosis questions based on a Journal of Investigative Dermatology article and includes explanations but reports no original research findings.

research 176 Characterising Neurotransmitter Signalling in Human Skin and Hair Follicles

November 2024 in “Journal of Investigative Dermatology”

Skin and hair cells release serotonin and histamine naturally, which could help improve skin health.

research 442 Deciphering the role of keloid fibroblasts in itch

November 2025 in “Journal of Investigative Dermatology”

Keloid fibroblasts cause itch and pain by releasing more histamine.

research Mechanical stimulation of human hair follicle outer root sheath cultures activates adjacent sensory neurons

2 citations , October 2023 in “Science advances”

In this study, researchers demonstrated that human hair follicle outer root sheath cells release ATP, serotonin, and histamine in response to mechanical stimulation, which subsequently activates surrounding sensory neurons.

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Community Join

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community Does anyone else sneeze or have their nose run when they microneedle their scalp?

in Microneedling 23 upvotes 2 years ago

Microneedling the scalp can cause sneezing, runny nose, and watery eyes due to nerve stimulation, histamine release, reflex actions, or sinus relief. Several users experience similar symptoms.

community Finally Scalp Folliculitis-Free after 2 Decades of Suffering

64 upvotes 1 year ago

A 37-year-old male resolved scalp folliculitis by adopting a low-histamine diet and taking Vitamin A, Zinc, and Fish Oil, leading to better skin health and thicker hair. He warns about the potential toxicity of excessive Vitamin A intake.

community Losing ground with minoxidil and finasteride

in Finasteride/Dutasteride 74 upvotes 11 months ago

A user experienced initial improvement with finasteride and minoxidil but is now losing progress and considering switching to dutasteride. Others suggest seasonal shedding, vitamin D deficiency, or trying dutasteride, while some share personal experiences with shedding cycles and treatment adjustments.

community Anyone else have sneezing reflex when starting microneedle?

in Microneedling 55 upvotes 2 years ago

Microneedling can cause a sneezing reflex due to tingling in the nose. Users report this reaction, especially in the temple region.

community 21M cant stop hairloss at all +2 years on dut/fin

9 upvotes 11 months ago

A 21-year-old male has been experiencing persistent hair loss despite using treatments like dutasteride, finasteride, RU58841, minoxidil, and ketoconazole. Suggestions include checking for hormonal issues, nutritional deficiencies, or allergies, and consulting a doctor for professional advice.

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Learn

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learn histidine

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