SnapshotDx Quiz: February 2018

The "SnapshotDx Quiz: February 2018" presented a case of a 30-year-old female with alopecia diagnosed as discoid lupus erythematosus (DLE) and included questions on cutaneous lupus erythematosus (CLE). Scholtissek et al. demonstrated that keratinocytes produce the cytokine CXCL10 in response to endogenous nucleic acids, recruiting CXCR3+ cytotoxic immune cells and contributing to CLE inflammation. UV radiation exacerbated this by increasing CXCL10 expression. Blocking pathogen recognition receptor pathways with kinase inhibitors was suggested as a potential therapeutic target for CLE. Other mechanisms like antigen presentation, histamine release, autophagy, and UVB-induced mutations were discussed but not supported by their findings.